Kuroda Hajime, Sakamoto Goi, Ohnisi Kiyoshi, Itoyama Shinji
Saitama Medical Center, Saitama Medical School, 1981, Tsujido, Kamoda, Kawagoe, Saitama 350-8550, Japan.
Breast Cancer. 2005;12(3):189-95. doi: 10.2325/jbcs.12.189.
Twenty cases of invasive ductal carcinoma of the breast with a pure or partial glycogen-rich clear cell carcinoma(GRCC)component are reported. GRCC of the breast is composed almost entirely of polygonal cells with clear cytoplasm. These contain large amounts of partly water-soluble glycogen.
The cases were analyzed using various parameters, including age at presentation, tumor size, tumor grade, axillary lymph node and Her2/neu status.
Between 1990 and 2004, 723 patients with primary breast carcinomas were treated and clinicopathologic analysis was performed. 20 cases were identified as GRCC among the 723 cases. The patients' age at presentation ranged from 33 to 68 years (mean, 52 years). Tumor size ranged from 1 to 6.5 cm (mean, 2.6 cm); 35% (7 of 20) of cases that underwent axillary dissection had positive lymph nodes. Among 15 of 20 cases who were followed for 1-72 months, 5 cases died from their breast carcinoma within 5 years following the diagnosis.
Our series included more small size carcinomas than did previous series. Lymph node status does not appear to be markedly different from that of the usual invasive ductal carcinomas. Her2/neu expression was similar to that found in common breast carcinomas.
报告了20例乳腺浸润性导管癌，伴有纯或部分富含糖原的透明细胞癌（GRCC）成分。乳腺GRCC几乎完全由细胞质透明的多边形细胞组成。这些细胞含有大量部分水溶性糖原。
使用各种参数对这些病例进行分析，包括就诊年龄、肿瘤大小、肿瘤分级、腋窝淋巴结和Her2/neu状态。
1990年至2004年间，723例原发性乳腺癌患者接受了治疗并进行了临床病理分析。在723例病例中，有20例被鉴定为GRCC。患者就诊年龄范围为33至68岁（平均52岁）。肿瘤大小范围为1至6.5厘米（平均2.6厘米）；接受腋窝清扫的病例中有35%（20例中的7例）淋巴结阳性。在20例中有15例随访了1至72个月，其中5例在诊断后5年内死于乳腺癌。
我们的系列病例中，小尺寸癌比以前的系列更多。淋巴结状态似乎与普通浸润性导管癌没有明显差异。Her2/neu表达与常见乳腺癌中的表达相似。
