Hayes M M, Seidman J D, Ashton M A
Pathology Laboratory, British Columbia Cancer Agency, Vancouver, Canada.
Am J Surg Pathol. 1995 Aug;19(8):904-11. doi: 10.1097/00000478-199508000-00005.
Twenty-one glycogen-rich clear cell carcinomas of the breast were studied. There were 13 invasive carcinomas and 8 intraductal carcinomas. Ten of the invasive carcinomas contained an intraductal component. Three intraductal carcinomas were papillary carcinomas ("intracystic" papillary carcinoma), and the others showed a mixture of solid, micropapillary, and cribriform patterns of growth. Most of the invasive carcinomas had nested, corded, or sheet-like growth patterns, and all were grade 2 or 3 neoplasms. Among patients with invasive carcinoma, two had metastases to axillary lymph nodes and three died of tumor. One patient with intraductal papillary carcinoma experienced two local recurrences, with invasion in the second recurrence. Thirteen cases (62%) exhibited focal apocrine features. Based on this small series, the clear cell morphology did not appear to influence the clinical outcome once stage and grade were taken into account. Glycogen-rich clear cell carcinoma of the breast may be a variant of apocrine carcinoma.
对21例乳腺富含糖原的透明细胞癌进行了研究。其中有13例浸润性癌和8例导管内癌。10例浸润性癌含有导管内成分。3例导管内癌为乳头状癌（“囊内”乳头状癌），其他表现为实性、微乳头状和筛状生长模式的混合。大多数浸润性癌具有巢状、条索状或片状生长模式，均为2级或3级肿瘤。在浸润性癌患者中，2例发生腋窝淋巴结转移，3例死于肿瘤。1例导管内乳头状癌患者出现2次局部复发，第二次复发时发生浸润。13例（62%）表现出局灶性大汗腺特征。基于这一小系列病例，一旦考虑分期和分级，透明细胞形态似乎并不影响临床结局。乳腺富含糖原的透明细胞癌可能是大汗腺癌的一种变体。
