Comhaire F H, El Garem Y, Mahmoud A, Eertmans F, Schoonjans F
Ghent University Hospital, Department of Medical and Urological Andrology, 9k12 IE, De Pintelaan, 185, B 9000, Gent, Belgium.
Asian J Androl. 2005 Sep;7(3):257-62. doi: 10.1111/j.1745-7262.2005.00047.x.
To evaluate the treatment of male infertility with a strong natural antioxidant, in addition to conventional treatment.
Using a double blind, randomized trial design, 30 men with infertility of > or =2 months and female partners with no demonstrable cause of infertility received conventional treatment according to the guidelines of the World Health Organization (WHO), and either a strong antioxidant Astaxanthin 16 mg/day (AstaCarox, AstaReal AB, Gustavsberg, Sweden) or placebo for 3 months. The effects of treatment on semen parameters, reactive oxygen species (ROS), zona-free hamster oocyte test, serum hormones including testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and Inhibin B, and spontaneous or intrauterine insemination (IUI)-induced pregnancies were evaluated.
ROS and Inhibin B decreased significantly and sperm linear velocity increased in the Astaxanthin group (n = 11), but not in the placebo group (n = 19). The results of the zona-free hamster oocyte test tended to improve in the Astaxanthin group in contrast with the placebo group, though not reaching statistical significance. The total and per cycle pregnancy rates among the placebo cases (10.5 % and 3.6 %) were lower compared with 54.5 % and 23.1 % respectively in the Astaxanthin group (P = 0.028; P = 0.036).
Although the present study suggests a positive effect of Astaxanthin on sperm parameters and fertility, the results need to be confirmed in a larger trial before recommending Astaxanthin for the complementary treatment of infertile men.
除常规治疗外，评估一种强效天然抗氧化剂对男性不育症的治疗效果。
采用双盲、随机试验设计，30名不育时间≥2个月且其女性伴侣无明显不育原因的男性，根据世界卫生组织（WHO）的指南接受常规治疗，并随机分为两组，一组每天服用16毫克强效抗氧化剂虾青素（AstaCarox，瑞典哥德堡AstaReal AB公司生产），另一组服用安慰剂，为期3个月。评估治疗对精液参数、活性氧（ROS）、去透明带仓鼠卵母细胞试验、包括睾酮、黄体生成素（LH）、卵泡刺激素（FSH）和抑制素B在内的血清激素以及自然受孕或宫腔内人工授精（IUI）诱导受孕的影响。
虾青素组（n = 11）的ROS和抑制素B显著降低，精子直线速度增加，而安慰剂组（n = 19）则无此变化。与安慰剂组相比，虾青素组的去透明带仓鼠卵母细胞试验结果有改善趋势，但未达到统计学意义。安慰剂组的总妊娠率和每个周期妊娠率分别为10.5%和3.6%，低于虾青素组的54.5%和23.1%（P = 0.028；P = 0.036）。
尽管本研究表明虾青素对精子参数和生育能力有积极影响，但在推荐虾青素作为不育男性的辅助治疗方法之前，需要在更大规模的试验中对结果进行验证。
