Currie P J, Wilson L M
Section of Biopsychology, Clarke Institute of Psychiatry, Toronto, ON, Canada.
Neuroreport. 1992 Jan;3(1):59-61. doi: 10.1097/00001756-199201000-00015.
The effects of intracerebroventricular (ICV) administration of 5-hydroxytryptamine creatinine sulphate complex (5-HT), 35-140 nmol, on food intake in genetically obese (ob/ob) and lean mice were investigated. 5-HT (70-140 nmol) decreased feeding in a dose-related manner on 1 h and 2 h postinjection measures. Intake in lean mice was reduced by over 70% of the control condition. Obese mice, however, demonstrated a reduced sensitivity to the anorectic effect of 5-HT, and reduced 1 h intake by only 40% of saline control. Although these results are consisted with a role for serotonin in the control of food intake in mice, the altered sensitivity of the ob/ob to serotonergic stimulation may result, in part, from an impaired satiety control mechanism in this mutant.
研究了向脑室内（ICV）注射35 - 140纳摩尔硫酸5-羟色胺肌酸酐复合物（5-HT）对遗传性肥胖（ob/ob）小鼠和瘦小鼠食物摄入量的影响。在注射后1小时和2小时的测量中，5-HT（70 - 140纳摩尔）以剂量相关的方式减少进食。瘦小鼠的摄入量比对照条件减少了70%以上。然而，肥胖小鼠对5-HT的厌食作用敏感性降低，1小时摄入量仅比生理盐水对照减少40%。尽管这些结果与血清素在小鼠食物摄入控制中的作用一致，但ob/ob小鼠对血清素能刺激的敏感性改变可能部分是由于该突变体中饱腹感控制机制受损所致。
