Balster S, Schiborr M, Brinkmann O A, Hertle L
Klinik und Poliklinik für Urologie, Universitätsklinikum Münster.
Aktuelle Urol. 2005 Aug;36(4):317-28. doi: 10.1055/s-2005-870934.
"Obstructive uropathy" is a generic term which combines different diseases in infants and childhood. Both the upper and lower urinary tract may be affected. Diseases of the urinary tract can cause an intrinsic obstruction. Sometimes tumours may cause a compression and as secondary effect an obstruction (extrinsic). Ultrasound is the key diagnostic tool and shows dilatation of the obstructed urinary tract. But for the functional exploration of babies and toddlers, renal scanning and X-ray examinations are necessary. These examinations lead to an exposure to radiation which necessitates careful indication. Some of the congenital diseases (for example ureteropelvic junction obstruction, megaureter) show a maturation without any intervention. So one has to decide whether to wait and see or to operate. A percutaneous nephrostomy or a DJ-catheter is not often used in the treatment of obstruction in general. These forms of drainage are more often used in the treatment of stones or of extrinsic obstruction. A pyelocutaneostomy or ureterocutaneostomy is a special surgical procedure in pediatric urology for transient drainage of the upper urinary tract (megaureter). The operation of a seriously ill new-born should be done in a centre for pediatric urology and pediatric nephrology. When the upper urinary tract is dilated, patients may need an antibiotic prophylaxis, because the dilatation of the upper urinary tract increases the risk of urinary tract infections (UTI). The indication for antibiotic prophylaxis should by guided by the criteria of the APN-Consensus Paper. Long-term follow-up is necessary and should comprise ultrasound, physical examination, controlling the blood pressure, urine analysis and blood tests. The aims of diagnostics, treatment and long-term follow-up are the preservation of renal function and to protect the children from UTI. This goal must be reached under conditions that are appropriate for children and their parents.
“梗阻性尿路病”是一个通用术语,涵盖婴幼儿期的多种不同疾病。上尿路和下尿路均可受累。泌尿系统疾病可导致内在梗阻。有时肿瘤可引起压迫,继而造成梗阻(外在梗阻)。超声是关键的诊断工具,可显示梗阻尿路的扩张情况。但对于婴幼儿的功能检查,肾脏扫描和X线检查是必要的。这些检查会使患儿暴露于辐射之下,因此需要谨慎掌握适应症。一些先天性疾病(如肾盂输尿管连接部梗阻、巨输尿管)可自行成熟,无需干预。所以必须决定是等待观察还是进行手术。一般来说,经皮肾造瘘术或双J管置入术在梗阻治疗中并不常用。这些引流方式更多用于结石或外在梗阻的治疗。肾盂皮肤造口术或输尿管皮肤造口术是小儿泌尿外科用于上尿路(巨输尿管)临时引流的一种特殊外科手术。病情严重的新生儿手术应在小儿泌尿外科和小儿肾脏病中心进行。当上尿路扩张时,患者可能需要预防性使用抗生素,因为上尿路扩张会增加尿路感染(UTI)的风险。预防性使用抗生素的适应症应以APN共识文件的标准为指导。需要进行长期随访,应包括超声检查、体格检查、血压监测、尿液分析和血液检查。诊断、治疗和长期随访的目的是保护肾功能,防止儿童发生尿路感染。这一目标必须在适合儿童及其家长的条件下实现。