Chen Qimin, Cai Jinquan, Shi Chengren, Sun Jie, Yin Minzhi, Shen Ping
Department of Urology, Shanghai Children's Medical Center affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127;
Exp Ther Med. 2013 Mar;5(3):767-770. doi: 10.3892/etm.2013.888. Epub 2013 Jan 7.
The aim of this study was to observe the development and distribution of autogenous nerves in the urinary tract of New Zealand rabbits. Animals of various ages were used in this study, including 2, 3 and 3.5 weeks (gestational ages) and 1, 4, 8 and 12 weeks (postnatal). Samples were selected at various sites of the urinary tract. Immunohistochemical staining methods were used to investigate the nervous plexus and neuroganglia on the wall of the urinary tract. Myenteric plexuses and ganglia first appeared at the gestational age of 3 weeks. They decreased in the pelvis and ureter as the animals developed, until at the end of postnatal week 8, all nerves disappeared completely. However, nerves existed in the bladder and posterior urethra permanently. The development and distribution of myenteric nerves is different between the upper and lower part of the urinary tract. Our study aimed to investigate this further.
本研究的目的是观察新西兰兔泌尿道中自主神经的发育和分布。本研究使用了不同年龄的动物，包括2、3和3.5周（胎龄）以及1、4、8和12周（出生后）。在泌尿道的不同部位选取样本。采用免疫组织化学染色方法研究泌尿道壁上的神经丛和神经节。肌间神经丛和神经节最早出现在胎龄3周时。随着动物的发育，它们在盆腔和输尿管中减少，直到出生后第8周结束时，所有神经完全消失。然而，神经在膀胱和后尿道中永久存在。泌尿道上部和下部的肌间神经发育和分布不同。我们的研究旨在进一步对此进行调查。
