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[孕期酒精对后代皮质毛细血管超微结构的中度影响]

[Prenatal moderate effects of alcohol on ultrastructure of cortical capillaries in the offspring].

作者信息

Popova E N

出版信息

Biull Eksp Biol Med. 1992 Feb;113(2):161-4.

PMID:1611064
Abstract

Sensorimotor cortex of rat 21- and 30-day-old offspring given prenatally moderate alcohol doses revealed signs of hemodynamic, ultrastructural capillary and compensatory-adaptive changes. The 60-day-old offspring displayed the tendency to hemodynamic and ultrastructural reversibility in remaining edema of the pericapillary processes of astrocytes. It is suggested that the deficiency of cerebral circulation is a delayed aftereffect of prenatal brain hypoxia. Under alcohol intoxication before pregnancy the edema was not observed. There was polymorphism of ultrastructure of cortical capillaries and immature vessels in the offspring.

摘要

对产前给予中等剂量酒精的21日龄和30日龄大鼠后代的感觉运动皮层进行研究,发现其存在血流动力学、超微结构毛细血管以及代偿性适应性变化的迹象。60日龄的后代在星形胶质细胞毛细血管周围突剩余水肿方面表现出血流动力学和超微结构可逆性的趋势。研究表明,脑循环不足是产前脑缺氧的延迟后遗症。妊娠前酒精中毒时未观察到水肿。后代的皮质毛细血管和未成熟血管存在超微结构多态性。

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