由偶氮甲烷（AOM）和2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶（PhIP）在经X射线照射导致肠化生的F344大鼠胃黏膜中诱导肿瘤。
Tumor induction by azoxymethane (AOM) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in F344 rat gastric mucosa featuring intestinal metaplasia caused by X-irradiation.
作者信息
Kashiwabara S, Kashimoto N, Uesaka T, Wakabayashi K, Kamiya K, Watanabe H
机构信息
Dept. of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
出版信息
J Exp Clin Cancer Res. 2005 Jun;24(2):305-12.
Male F344 5-week-old rats were X-irradiated, and 16 weeks after the first dose, azoxymethane (AOM) was injected or 2-amino-1 -methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) was given by intragastric intubation. Tumors in the pylorus of the glandular stomach were observed in 4 out of the 29 animals receiving X-rays + AOM and in 4 out of the 25 animals receiving X-rays + PhIP, 12 months after administration. No such lesions were found in the chemical or X-ray alone groups. Intestinal metaplasia and some induced tumors were positive for CDX2. It was concluded that the presence of intestinal metaplasia may increase sensitivity to the induction of gastric tumors by colon carcinogens.
对5周龄雄性F344大鼠进行X射线照射，在首次照射剂量16周后，注射偶氮甲烷（AOM）或通过胃内插管给予2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶（PhIP）。给药12个月后，在接受X射线+AOM的29只动物中有4只以及接受X射线+PhIP的25只动物中有4只在腺胃幽门处观察到肿瘤。在单独使用化学物质或X射线的组中未发现此类病变。肠化生和一些诱导肿瘤的CDX2呈阳性。得出的结论是，肠化生的存在可能会增加对结肠致癌物诱导胃肿瘤的敏感性。
Zotero 插件