Watanabe H, Fujimoto N, Masaoka Y, Kurosumi M, Oguri T, Takahashi T, Kido S, Hirata S, Kuramoto K, Shoji S, Katoh O
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima, 734-8553, Japan.
Oncol Rep. 1998 Jul-Aug;5(4):837-40. doi: 10.3892/or.5.4.837.
The present study was undertaken to determine the effect of azoxymethane (AOM) administration on intestinal metaplasia induced by X-irradiation in male Donryu rats. Five-week-old animals were X-irradiated with two doses of 10 Gy each at a 3-day interval or three X-ray doses of 10 Gy at a 2-day interval and then received AOM injections i.m. at a dose of 15 mg/kg body weight once weekly for 3 weeks, 6 months after irradiation. Alkaline phosphatase positive foci were decreased after AOM treatments, but aberrant crypt like-foci appeared within areas of intestinal metaplasia. In contrast no induction was observed in normal-appearing gastric mucosa.
本研究旨在确定给予雄性唐育大鼠偶氮甲烷（AOM）对X射线诱导的肠化生的影响。5周龄的动物接受两次间隔3天、每次剂量为10 Gy的X射线照射，或三次间隔2天、每次剂量为10 Gy的X射线照射，然后在照射后6个月接受AOM肌肉注射，剂量为15 mg/kg体重，每周一次，共3周。AOM处理后碱性磷酸酶阳性灶减少，但在肠化生区域内出现了异常隐窝样病灶。相比之下，在外观正常的胃黏膜中未观察到诱导现象。
