Lin Li-Lin, Huang Feng, Chen Si-Bao, Yang Da-Jian, Chen Shi-Lin, Yang Jun-Shan, Xiao Pei-Gen
Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100094, China.
Zhongguo Zhong Yao Za Zhi. 2005 Jun;30(11):827-30.
To study the chemical constituents in roots of P. fallax and their anti-oxidation activities in vitro.
Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant. The structures were elucidated on the basis of the spectral evidence and the physical and chemical character. The isolated compounds were screened with four anti-oxidation models in vitro.
Seven xanthones, 1,7-dihydroxy-2,3-methylenedioxyxanthone (1), 1-methoxy-2,3-methylenedioxyxanthone (2), 3-hydroxy-1,2-dimethoxyxanthone (3), 1,6,7-trihydroxy-2,3-dimethoxyxanthone (4), 7-hydroxy-1-methoxy-2,3-methylenedioxyxanthone (5), 1,3-dihydroxy-2-methoxyxanthone (6) and 1,3,7-trihydroxy-2-methoxyxanthone (7), were isolated from the roots of P. fallax. And compounds 1 - 7 showed different anti-oxidation activities in the different pharmacological models.
Compounds 2, 3, 5 and 7 were isolated from this plant for the first time. Xanthones from this plant showed anti-oxidation activities. The pharmacological activities of the pure compounds from this plant were also reported for the first time.
研究紫花络石根中的化学成分及其体外抗氧化活性。
采用柱色谱技术对该植物的化学成分进行分离和纯化。根据光谱数据以及理化性质对化合物结构进行鉴定。采用四种体外抗氧化模型对分离得到的化合物进行筛选。
从紫花络石根中分离得到7种呫吨酮类化合物，分别为1,7 - 二羟基 - 2,3 - 亚甲二氧基呫吨酮（1）、1 - 甲氧基 - 2,3 - 亚甲二氧基呫吨酮（2）、3 - 羟基 - 1,2 - 二甲氧基呫吨酮（3）、1,6,7 - 三羟基 - 2,3 - 二甲氧基呫吨酮（4）、7 - 羟基 - 1 - 甲氧基 - 2,3 - 亚甲二氧基呫吨酮（5）、1,3 - 二羟基 - 2 - 甲氧基呫吨酮（6）和1,3,7 - 三羟基 - 2 - 甲氧基呫吨酮（7）。化合物1 - 7在不同药理模型中表现出不同的抗氧化活性。
化合物2、3、5和7为首次从该植物中分离得到。该植物中的呫吨酮类化合物具有抗氧化活性。该植物中纯化合物的药理活性也为首次报道。
