Kodama T, Tomiyama T, Ishizaki T, Baba T
Hakodate Ishikai Hospital, Japan.
J Diabetes Complications. 1992 Apr-Jun;6(2):70-6. doi: 10.1016/1056-8727(92)90015-d.
To determine if non-insulin-dependent diabetes mellitus (NIDDM) patients with microalbuminuria would have augmented vascular risk factors, we studied the relationships between blood pressure, serum lipids, plasma fibrinogen, and uric acid concentrations and plasma lipoprotein (a) level in 25 Japanese NIDDM patients with microalbuminuria [albumin excretion rate (AER) 20-200 micrograms/min] and 25 individually pair-matched NIDDM patients with normal urinary albumin excretion (AER less than 20 micrograms/min), matched for age, sex, body mass index, treatment and HbAlc level. Microalbuminuric patients had significantly higher systolic blood pressure (p less than 0.05) and plasma fibrinogen level (p less than 0.05) and lower high-density lipoprotein (HDL) cholesterol concentration (p less than 0.05) as compared with those in normoalbuminuric patients, respectively, while there were no differences in serum triglycerides and uric acid levels between the two groups. Plasma lipoprotein (a) level, assessed in 15 microalbuminuric and 15 normoalbuminuric patients, was comparable in the two groups. The results suggest that some of the vascular risk factors are already present in microalbuminuric NIDDM patients when compared with normoalbuminuric patients.
为了确定微量白蛋白尿的非胰岛素依赖型糖尿病（NIDDM）患者是否有增加的血管危险因素，我们研究了25例日本微量白蛋白尿的NIDDM患者[白蛋白排泄率（AER）20 - 200微克/分钟]和25例个体配对的尿白蛋白排泄正常（AER小于20微克/分钟）的NIDDM患者的血压、血脂、血浆纤维蛋白原、尿酸浓度与血浆脂蛋白（a）水平之间的关系，这些患者在年龄、性别、体重指数、治疗和糖化血红蛋白水平方面进行了匹配。与正常白蛋白尿患者相比，微量白蛋白尿患者的收缩压（p < 0.05）和血浆纤维蛋白原水平（p < 0.05）显著更高，高密度脂蛋白（HDL）胆固醇浓度更低（p < 0.05），而两组之间的血清甘油三酯和尿酸水平没有差异。在15例微量白蛋白尿患者和15例正常白蛋白尿患者中评估的血浆脂蛋白（a）水平在两组中相当。结果表明，与正常白蛋白尿患者相比，微量白蛋白尿的NIDDM患者已经存在一些血管危险因素。
