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脑桥向小脑两侧的不同投射。

Different pontine projections to the two sides of the cerebellum.

作者信息

Cicirata Federico, Zappalà Agata, Serapide Maria Francesca, Parenti Rosalba, Pantò Maria Rosita, Paz Carlos

机构信息

Dipartimento di Scienze Fisiologiche, Viale A. Doria 6, 95125 Catania, Italy.

出版信息

Brain Res Brain Res Rev. 2005 Sep;49(2):280-94. doi: 10.1016/j.brainresrev.2005.02.002. Epub 2005 Mar 23.

Abstract

This study analyzed the projections of the basilar pontine nuclei (BPN) and of the nucleus reticularis tegmenti pontis (NRTP) to the two sides of the cerebellum in the rat. It showed that the two sides of the cerebellar cortex were innervated by different percentages of BPN (about 82% of the cells project to the contralateral cortex and 18% to the ipsilateral) and NRTP cells (some 60% project to the contralateral cortex and 40% to the ipsilateral). In comparison to projections traced to the cortex, only a few fibers were traced to the nuclei of the same animals. Most of the projections of the BPN to the cerebellar nuclei were traced to the lateralis and posterior interpositus nucleus of the contralateral side (95%), while a few were traced to homologous nuclei of the ipsilateral side (5%). Thus, the BPN principally control the activity of the contralateral cerebellum, with a much less important control over the activity of the ipsilateral cerebellum. Vice versa, the NRTP, which project to the lateralis, interpositus, and medialis nuclei of the two sides, with percentages (64% contra- and 36% ipsilateral) similar to those reported for the projections to the cortex, is more concerned in the bilateral control of the cerebellum, although with a moderate contralateral prevalence. The fact that projections of the BPN were principally traced to the contralateral nuclei, from which the efferent projection fibers from the cerebellum originate, suggests that the BPN are principally involved in the motor control of the contralateral body. Conversely, the bilateral projections of the NRTP to the cerebellar nuclei suggest that the NRTP is mainly involved in bilateral motor activities. The comparison of the projections to the cortex and nuclei of the cerebellum of single animals supports the co-existence of coupled (i.e., projections to the cortex and the corresponding nuclei) and uncoupled (i.e., projections to the cortex but not to the nuclei) projection patterns, from both the BPN and the NRTP. These features of the pontocerebellar projections open new vistas on the functional architecture of this pathway.

摘要

本研究分析了大鼠脑桥基底部核(BPN)和脑桥被盖网状核(NRTP)向小脑两侧的投射。结果显示,小脑皮质两侧由不同比例的BPN(约82%的细胞投射至对侧皮质,18%投射至同侧)和NRTP细胞(约60%投射至对侧皮质,40%投射至同侧)支配。与追踪至皮质的投射相比,追踪至同一只动物核团的纤维较少。BPN向小脑核团的大部分投射追踪至对侧的外侧核和后间位核(95%),而少数投射至同侧的同源核团(5%)。因此,BPN主要控制对侧小脑的活动,对同侧小脑活动的控制作用小得多。反之,投射至两侧外侧核、间位核和内侧核的NRTP,其投射比例(对侧64%,同侧36%)与投射至皮质的比例相似,虽然对侧占优势,但更参与小脑的双侧控制。BPN的投射主要追踪至对侧核团,而小脑的传出投射纤维起源于这些核团,这一事实表明BPN主要参与对侧身体的运动控制。相反,NRTP向小脑核团的双侧投射表明,NRTP主要参与双侧运动活动。对单只动物小脑皮质和核团投射的比较支持了BPN和NRTP耦合(即投射至皮质和相应核团)和非耦合(即投射至皮质但不投射至核团)投射模式的共存。脑桥小脑投射的这些特征为该通路的功能结构开辟了新的视野。

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