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大鼠间位核与外侧小脑核至脑桥小脑投射的放射自显影研究

An autoradiographic study of the cerebellopontine projections from the interposed and lateral cerebellar nuclei in the rat.

作者信息

Angaut P, Cicirata F, Pantò M R

出版信息

J Hirnforsch. 1985;26(4):463-70.

PMID:4067284
Abstract

The projections from the cerebellar lateral and interposed nuclei onto the basilar pontine gray and nucleus reticularis tegmenti pontis (NRTP) have been studied in the rat by the use of the autoradiographic technique. Projections from both nuclei are mainly contralateral. Fibers from the lateral nucleus cover most of the NRTP, except its medial, parvocellular portion. In the pontine gray proper, fibers from the lateral nucleus are distributed to three rostrocaudally oriented columns: (i) in the medial nucleus, (ii) in the ventral nucleus, and (iii) in the dorsolateral and lateral nuclei. The projection is topographically arranged, so that caudal parts of the lateral cerebellar nucleus tend to project to more rostral regions than rostral parts of the lateral nucleus. The interposed nucleus gives rise to a sparser projection, apparently limited to the ventral NRTP and immediate peripeduncular zones. The functional implications of these results are discussed, with particular emphasis on the convergence of corticopontine afferents to the pontine regions involved, and on the reciprocal pontocerebellar pathways from these same regions.

摘要

利用放射自显影技术,在大鼠中研究了小脑外侧核和间位核向脑桥基底神经节灰质和脑桥被盖网状核(NRTP)的投射。来自这两个核的投射主要是对侧的。来自外侧核的纤维覆盖了大部分NRTP,但不包括其内侧的小细胞部分。在脑桥固有灰质中,来自外侧核的纤维分布于三个前后方向排列的柱体:(i)内侧核;(ii)腹侧核;(iii)背外侧核和外侧核。这种投射是按拓扑结构排列的,因此小脑外侧核的尾部比外侧核的头部倾向于投射到更靠前的区域。间位核产生的投射较稀疏,显然仅限于腹侧NRTP和紧邻脚周的区域。讨论了这些结果的功能意义,特别强调了皮质脑桥传入纤维向所涉及的脑桥区域的汇聚,以及来自这些相同区域的相互脑桥小脑通路。

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