Proadrenomedullin N-terminal peptide and cortistatin activation of MrgX2 receptor is based on a common structural motif.
作者信息
Nothacker Hans-Peter, Wang Zhiwei, Zeng Hua, Mahata Sushil K, O'Connor Daniel T, Civelli Olivier
机构信息
Department of Pharmacology, 354 MedSurge II University of California, Irvine, Irvine CA 92697-4625, USA.
出版信息
Eur J Pharmacol. 2005 Sep 5;519(1-2):191-3. doi: 10.1016/j.ejphar.2005.07.001.
The G protein-coupled receptor MrgX2 belongs to the large family of the Mas-related genes or sensory neuron-specific G protein-coupled receptors. The MrgX2 receptor has been shown to be activated by the peptides cortistatin and proadrenomedullin N-terminal peptides (PAMP). Here we investigated the structure activity relationship of PAMP and identified key structural features that are shared with cortistatin and might explain why two apparently unrelated peptides are able to activate a single G protein-coupled receptor.
Zotero 插件