Fattorini L, Hu C Q, Jin S H, Santoro C, Tsang A Y, Mascellino M T, Mandler F, Orefici G
Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome, Italy.
Zentralbl Bakteriol. 1992 Apr;276(4):512-20.
Twenty-five strains of Mycobacterium avium-intracellulare (MAC) isolated from acquired immunodeficiency syndrome (AIDS) patients in three medical centres in Italy have been studied. Serotyping performed on eighteen strains showed various serovars within either M. avium or M. intracellulare serotypes and with serovars 1 and 21 being the most prevalent (four strains for each serovar). Among fourteen drugs used for testing the antibiotic sensitivity, rifapentine, rifabutin and clofazimine showed to have the best in vitro activity. In an ex vivo model of infection using peritoneal resting macrophages from the C57BL/6 mouse, the intracellular viability of a strain of M. avium (strain 489, serovar 3) was reduced by clofazimine, amikacin, ciprofloxacin, rifabutin and clarithromycin (99, 98, 93, 89 and 69%, respectively), thus indicating for clofazimine a good correlation between in vitro and ex vivo activity.
对从意大利三个医疗中心的获得性免疫缺陷综合征（AIDS）患者中分离出的25株鸟分枝杆菌-胞内分枝杆菌（MAC）进行了研究。对18株菌株进行的血清分型显示，在鸟分枝杆菌或胞内分枝杆菌血清型中存在多种血清型，其中血清型1和21最为常见（每种血清型各有4株）。在用于测试抗生素敏感性的14种药物中，利福喷汀、利福布汀和氯法齐明显示出最佳的体外活性。在使用C57BL/6小鼠腹腔静止巨噬细胞的体外感染模型中，氯法齐明、阿米卡星、环丙沙星、利福布汀和克拉霉素降低了一株鸟分枝杆菌（菌株489，血清型3）的细胞内存活率（分别为99%、98%、93%、89%和69%），因此表明氯法齐明的体外和体外活性之间具有良好的相关性。
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