Arita Makoto, Clish Clary B, Serhan Charles N
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Biochem Biophys Res Commun. 2005 Dec 9;338(1):149-57. doi: 10.1016/j.bbrc.2005.07.181. Epub 2005 Aug 10.
Resolvins (Rvs) are oxygenated products derived from omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid that carry potent protective bioactions present in resolving inflammatory exudates. Resolvin E1 (RvE1) is biosynthesized in vivo from EPA via transcellular biosynthetic routes during cell-cell interactions, and thus RvE1 is formed in vivo during multicellular responses such as inflammation and microbial infections. RvE1 protects tissues from leukocyte-mediated injury and counterregulates proinflammatory gene expression. These newly identified Rvs may underlie the beneficial actions of omega-3 PUFAs especially in chronic disorders where unresolved inflammation is a key mechanism of pathogenesis. Here, we present an overview of the biosynthesis of RvE1, with a focus on the aspirin-triggered and microbial P450-initiated pathways. The generation of RvE1 and its actions appear to dampen acute leukocyte responses and facilitate the resolution of inflammation.
消退素（Rvs）是由ω-3多不饱和脂肪酸（PUFAs）如二十碳五烯酸（EPA）和二十二碳六烯酸衍生而来的氧化产物，这些脂肪酸具有存在于消退炎症渗出物中的强大保护生物活性。消退素E1（RvE1）在细胞间相互作用过程中通过跨细胞生物合成途径由EPA在体内生物合成，因此RvE1在诸如炎症和微生物感染等多细胞反应过程中在体内形成。RvE1保护组织免受白细胞介导的损伤，并对抗调节促炎基因表达。这些新发现的消退素可能是ω-3多不饱和脂肪酸有益作用的基础，尤其是在未解决的炎症是发病机制关键机制的慢性疾病中。在此，我们概述RvE1的生物合成，重点关注阿司匹林触发和微生物细胞色素P450启动的途径。RvE1的产生及其作用似乎可减轻急性白细胞反应并促进炎症的消退。
