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145株严重急性呼吸综合征冠状病毒的分子进化与多位点序列分型

Molecular evolution and multilocus sequence typing of 145 strains of SARS-CoV.

作者信息

Wang Zhi-Gang, Zheng Zhi-Hua, Shang Lei, Li Lan-Juan, Cong Li-Ming, Feng Ming-Guang, Luo Yun, Cheng Su-Yun, Zhang Yan-Jun, Ru Miao-Gui, Wang Zan-Xin, Bao Qi-Yu

机构信息

Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310009, China.

出版信息

FEBS Lett. 2005 Sep 12;579(22):4928-36. doi: 10.1016/j.febslet.2005.07.075.

DOI:10.1016/j.febslet.2005.07.075
PMID:16112670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7118731/
Abstract

In this study, we have identified 876 polymorphism sites in 145 complete or partial genomes of SARS-CoV available in the NCBI GenBank. One hundred and seventy-four of these sites existed in two or more SARS-CoV genome sequences. According to the sequence polymorphism, all SARS-CoVs can be divided into three groups: (I) group 1, animal-origin viruses (such as SARS-CoV SZ1, SZ3, SZ13 and SZ16); (II) group 2, all viruses with clinical origin during first epidemic; and (III) group 3, SARS-CoV GD03T0013. According to 10 special loci, group 2 again can be divided into genotypes C and T, which can be further divided into sub-genotypes C1-C4 and T1-T4. Positive Darwinian selections were identified between any pair of these three groups. Genotype C gives neutral selection. Genotype T, however, shows negative selection. By comparing the death rates of SARS patients in the different regions, it was found that the death rate caused by the viruses of the genotype C was lower than that of the genotype T. SARS-CoVs might originate from an unknown ancestor.

摘要

在本研究中，我们在NCBI基因库中可获取的145个严重急性呼吸综合征冠状病毒（SARS-CoV）完整或部分基因组中鉴定出876个多态性位点。其中174个位点存在于两个或更多SARS-CoV基因组序列中。根据序列多态性，所有SARS-CoV可分为三组：（I）第1组，动物源病毒（如SARS-CoV SZ1、SZ3、SZ13和SZ16）；（II）第2组，首次流行期间所有临床来源的病毒；以及（III）第3组，SARS-CoV GD03T0013。根据10个特殊位点，第2组又可分为基因型C和T，它们可进一步分为子基因型C1 - C4和T1 - T4。在这三组中的任意两组之间均鉴定出正达尔文选择。基因型C呈现中性选择。然而，基因型T显示负选择。通过比较不同地区SARS患者的死亡率，发现由基因型C病毒引起的死亡率低于基因型T。SARS-CoV可能起源于一个未知的祖先。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/7298156/e80804c558c1/FEB2-579-4928-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/7298156/5b0bec437aa8/FEB2-579-4928-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/7298156/e0a1a243375a/FEB2-579-4928-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/7298156/be7197fa41a5/FEB2-579-4928-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/7298156/e80804c558c1/FEB2-579-4928-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/7298156/5b0bec437aa8/FEB2-579-4928-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/7298156/e0a1a243375a/FEB2-579-4928-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/7298156/be7197fa41a5/FEB2-579-4928-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66c5/7298156/e80804c558c1/FEB2-579-4928-g004.jpg

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2
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Chin Sci Bull. 2003;48(12):1170-1174. doi: 10.1007/BF03183929.
3
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4
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Sci Rep. 2020 Oct 26;10(1):18289. doi: 10.1038/s41598-020-74050-8.
5
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6
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Cladistics. 2008 Apr;24(2):111-130. doi: 10.1111/j.1096-0031.2008.00199.x. Epub 2008 Feb 16.
7
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