Gel'tser B I, Koriakov A V, Butovets G V
Ross Med Zh. 1992(1):4-6.
The system proteinases-inhibitors and renin were studied in 105 acute pneumonia (AP) patients, the blood of whom was examined for concentrations of elastase, acid proteases (AP), alpha 1-inhibitor of proteases (alpha 1-IP), alpha 2-macroglobulin (alpha 2-MG) and active or inactive, total renin (TR). A separate group included 18 AP cases complicated by infective toxic shock (ITS). An imbalance was proved in the system proteinases-inhibitors with dominance of the inhibitory potential. In a "cold" variant of ITS proteolytic blood activity rose while the inhibitory capacity fell. Moderate and severe AP forms were associated with lowered blood levels of active R and elevated of inactive R, TR. In arterial hypotonia and ITS these changes were most demonstrable. Elastase, alpha 1-IP, alpha 2-MG and active R, inactive R, TR exhibited close correlation. The discussion covered mechanisms of hemodynamic disturbances in AP with consideration of depressed renin-angiotensin system and imbalance of proteinases and their inhibitors.
对105例急性肺炎（AP）患者的系统蛋白酶 - 抑制剂和肾素进行了研究，检测了他们血液中的弹性蛋白酶、酸性蛋白酶（AP）、蛋白酶α1抑制剂（α1 - IP）、α2 - 巨球蛋白（α2 - MG）以及活性或非活性总肾素（TR）的浓度。另外一组包括18例并发感染性中毒性休克（ITS）的AP病例。结果证明系统蛋白酶 - 抑制剂存在失衡，抑制潜能占优势。在ITS的“冷”型中，血液中的蛋白水解活性升高而抑制能力下降。中度和重度AP形式与血液中活性肾素水平降低以及非活性肾素、总肾素水平升高有关。在动脉低血压和ITS中，这些变化最为明显。弹性蛋白酶、α1 - IP、α2 - MG与活性肾素、非活性肾素、总肾素表现出密切相关性。讨论内容涉及AP血流动力学紊乱的机制，同时考虑了肾素 - 血管紧张素系统的抑制以及蛋白酶及其抑制剂的失衡。
