[Immunoglobulins in the mucous membrane of the stomach and duodenum in patients with peptic ulcer].

Immunofluorescence was used to detect incidence of immunoglobulins M, G, A and secretory immunoglobulin A in gastric and duodenal mucosa of 72 patients with peptic ulcer. In the aggravated disease, duodenal mucosa contains IgM and secretory IgA more frequently than gastric one which has in more cases IgG and IgA. In ulcer remission, immunoglobulins of all classes are less frequent finding in duodenal mucosa, IgM and secretory IgA occurring more often in gastric mucosa. In recurrent disease, the occurrence of immunoglobulins in gastric mucosa decreases, in duodenal mucosa this is true only for IgA and secretory IgA. Ulcer patients with the disease duration more than 10 years demonstrate immunoglobulins in gastric mucosa less frequently, most rare of them being IgM and secretory IgA (p less than 0.05). The above changes in local immunity suggest pathogenetic involvement of immune mechanisms and can precondition clinical features of ulcer.