Even-Ram Sharona, Yamada Kenneth M
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892-4370, USA.
Curr Opin Cell Biol. 2005 Oct;17(5):524-32. doi: 10.1016/j.ceb.2005.08.015.
The ability of cells to migrate within the extracellular matrix and to remodel it depends as much on the physical and biochemical characteristics of a particular matrix as on cellular properties. Analyzing the different modes of migration of cells in matrices, and how cells switch between these modes, is vital for understanding a variety of physiological and pathological processes. Recent work provides new insights, but also raises some debates about the mechanisms and regulation of cell migration in three-dimensional matrices.
细胞在细胞外基质中迁移并对其进行重塑的能力，既取决于特定基质的物理和生化特性，也取决于细胞自身特性。分析细胞在基质中的不同迁移模式以及细胞如何在这些模式之间转换，对于理解各种生理和病理过程至关重要。近期的研究工作提供了新的见解，但也引发了一些关于三维基质中细胞迁移机制和调控的争论。
