正常妊娠早期及稽留流产患者腹腔液中瘦素的浓度
Coelomic fluid leptin concentration in normal first-trimester pregnancies and missed miscarriages.
作者信息
Makrydimas G, Vandecruys H, Sotiriadis A, Lakasing L, Spencer K, Nicolaides K H
机构信息
Department of Obstetrics and Gynaecology, Ioannina University Hospital, Ioannina, Greece.
出版信息
Fetal Diagn Ther. 2005 Sep-Oct;20(5):406-9. doi: 10.1159/000086821.
OBJECTIVE
Investigation of the possible role of leptin in early pregnancy failure.
METHODS
Leptin concentration was measured in maternal serum, coelomic fluid and amniotic fluid from 15 singleton pregnancies with live fetuses and 7 missed miscarriages at 7-10 weeks of gestation.
RESULTS
In the pregnancies with live fetuses, the median leptin concentration was significantly higher in coelomic fluid (median 33.1 ng/ml) than in maternal serum (median 8.1 ng/ml) or amniotic fluid (median 0.5 ng/ml). In the pregnancies with missed miscarriage, compared to those with live fetuses, the median leptin concentration in coelomic fluid was higher (median 45.3 ng/ml), but in maternal serum it was not significantly different (median 5.5 ng/ml).
CONCLUSIONS
The high coelomic fluid leptin concentration suggests that embryonic death may be preceded by impaired oxygenation of the placenta that stimulates production of leptin.
目的
研究瘦素在早期妊娠失败中可能发挥的作用。
方法
测定了15例单胎活产妊娠及7例妊娠7 - 10周稽留流产孕妇的母血、腹腔液和羊水中的瘦素浓度。
结果
在单胎活产妊娠中，腹腔液中瘦素浓度中位数（33.1 ng/ml）显著高于母血（8.1 ng/ml）和羊水（0.5 ng/ml）。在稽留流产妊娠中，与单胎活产妊娠相比，腹腔液中瘦素浓度中位数较高（45.3 ng/ml），但母血中差异不显著（5.5 ng/ml）。
结论
腹腔液中高瘦素浓度表明，胚胎死亡可能先于胎盘氧合受损，后者刺激了瘦素的产生。
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