Malec D, Langwiński R
Acta Physiol Pol. 1979 Sep-Dec;30(5-6):589-95.
The effects of drugs changing serotonin activity in rats were studied observing changes in the anticataleptic action of amphetamine and ephedrine. It was observed that: 1) parachlorophenylalanine prolonged the anticataleptic action of ephedrine and, in part also, that of amphetamine, 2) methysergide alone exerted an anticataleptic effect and enhanced somewhat the same effect of both psychostimulating drugs used, 3) d, 1-tryptophan increased the intensity of catalepsy and reduced very significantly or abolished completely the anticataleptic action of ephedrine and amphetamine. These results support the view that the serotonin system exerts a suppressing effect on the central effects resulting from stimulation of catecholamine dependent functions.
通过观察苯丙胺和麻黄碱抗木僵作用的变化，研究了改变大鼠血清素活性的药物的作用。观察到：1）对氯苯丙氨酸延长了麻黄碱的抗木僵作用，部分也延长了苯丙胺的抗木僵作用；2）麦角新碱单独发挥抗木僵作用，并在一定程度上增强了所使用的两种精神刺激药物的相同作用；3）消旋色氨酸增加了僵住症的强度，并非常显著地降低或完全消除了麻黄碱和苯丙胺的抗木僵作用。这些结果支持了这样一种观点，即血清素系统对由刺激儿茶酚胺依赖性功能所产生的中枢效应发挥抑制作用。
