血清素在麻黄碱诱导的刻板行为和运动亢进中的作用。
The role of serotonin in ephedrine-induced stereotypy and hypermotility.
作者信息
Malec D, Langwiński R, Kruszewska A
出版信息
Arch Immunol Ther Exp (Warsz). 1976;24(6):829-36.
The influence of serotonin agents on stereotypy and hypermotility induced with ephedrine was studied. P-Chlorophenylalanine (PCPA), an inhibitor of serotonin synthesis, had no influence on stereotypy. In reserpinized animals, this reaction was intensified only after high doses of ephedrine (100 and 120 mg/kg), but the precursor of 5-HT synthesis, tryptophan, strongly antagonized stereotypy. Ephedrine-induced hypermotility in mice and rats was potentiated by PCPA. It is suggested that serotonin ephedrine-induced effects, similarly to previous observations with amphetamine.
研究了血清素制剂对麻黄碱诱导的刻板行为和运动亢进的影响。对氯苯丙氨酸（PCPA），一种血清素合成抑制剂，对刻板行为没有影响。在利血平化的动物中，只有在高剂量麻黄碱（100和120mg/kg）后这种反应才会增强，但5-羟色胺合成的前体色氨酸能强烈对抗刻板行为。PCPA增强了麻黄碱在小鼠和大鼠中诱导的运动亢进。有人提出，血清素对麻黄碱诱导的作用，类似于先前对苯丙胺的观察结果。
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