Kang Kyoung Ah, Bu Hyung Deuk, Park Dal Soo, Go Gyung Min, Jee Youngheun, Shin Taekyun, Hyun Jin Won
Department of Biochemistry, College of Medicine, Cheju National University, Jeju, 690-756 South Korea.
Phytother Res. 2005 Jun;19(6):506-10. doi: 10.1002/ptr.1692.
The antioxidant properties of the red seaweed Callophyllis japonica were investigated. An ethanol extract isolated from C. japonica exhibited intracellular reactive oxygen species, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and lipid peroxidation inhibitory activity. The radical scavenging activity of the extract protected the viability of Chinese hamster lung fibroblast (V79-4) cells exposed to H2O2. Furthermore, the extract reduced the proportion of apoptotic cells induced by H2O2, as demonstrated by decreased sub-G1 hypo-diploid cells and decreased apoptotic body formation. The extract also increased the activities of the cellular antioxidant enzymes, superoxide dismutase and catalase. Together, these findings suggest that C. japonica exhibits antioxidant properties.
对红藻日本刺叶藻的抗氧化特性进行了研究。从日本刺叶藻中分离得到的乙醇提取物表现出细胞内活性氧、1,1-二苯基-2-苦基肼（DPPH）自由基清除活性和脂质过氧化抑制活性。提取物的自由基清除活性保护了暴露于过氧化氢的中国仓鼠肺成纤维细胞（V79-4）的活力。此外，提取物降低了过氧化氢诱导的凋亡细胞比例，表现为亚G1期亚二倍体细胞减少和凋亡小体形成减少。提取物还提高了细胞抗氧化酶超氧化物歧化酶和过氧化氢酶的活性。这些发现共同表明，日本刺叶藻具有抗氧化特性。
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