Donker G A, Groenhof F, van der Veen W J
Universitair Medisch Centrum Groningen, Registratienetwerk Groningen, disciplinegroep Huisartsgeneeskunde, Groningen.
Ned Tijdschr Geneeskd. 2005 Jul 30;149(31):1742-7.
To obtain information on the frequency of and the indications for prescription of methylphenidate in general practices in the north-east of The Netherlands.
Descriptive.
Data were collected from 1998 to 2003 from 6 general practices in the north-east of The Netherlands (17 general practitioners, approximately 30,000 patients) that were affiliated to the Registration Network in Groningen. The number of new and existing patients who were prescribed methylphenidate was calculated by age group per 1000 person-years per calendar year. The indication on which the drug was prescribed was looked at, as was the number of patients who were referred to a specialist on that indication.
The number of new users per 1000 person-years more than doubled from 17 in 1999 to 42 in 2003. In all years studied the highest number of new users fell into the age group 5-9 years. The total number of users per 1000 person-years tripled (boys: 1.8 in 1998 and 6.2 in 2003; girls: 0.5 in 1998 and 0.8 in 2003). The prevalence of use in boys was 3 to 8 times as high as that of girls and increasing more quickly. In people under 59 years of age attention deficit hyperactivity disorder (ADHD) was the most frequent indication (55%). In the group aged > or = 60 years methylphenidate was mainly prescribed in the palliative phase of somatic morbidity. Over half of the 140 new patients (57%) were referred nor to a specialist in the year before neither in the year after the first prescription of methylphenidate.
获取荷兰东北部全科医疗中哌甲酯的处方频率及适应证信息。
描述性研究。
收集1998年至2003年荷兰东北部6家全科医疗（17名全科医生，约30000名患者）的数据，这些医疗单位隶属于格罗宁根登记网络。按年龄组计算每年每1000人年中开具哌甲酯的新患者和现有患者数量。查看开具该药物的适应证，以及因该适应证转诊至专科医生的患者数量。
每1000人年中新使用者的数量从1999年的17人增加到2003年的42人，增加了一倍多。在所有研究年份中，新使用者数量最多的年龄组为5 - 9岁。每1000人年中使用者的总数增加了两倍（男孩：1998年为1.8人，2003年为6.2人；女孩：1998年为0.5人，2003年为0.8人）。男孩的使用患病率是女孩的3至8倍，且增长更快。在59岁以下人群中，注意缺陷多动障碍（ADHD）是最常见的适应证（55%）。在60岁及以上年龄组中，哌甲酯主要在躯体疾病的姑息治疗阶段开具。140名新患者中有超过一半（57%）在首次开具哌甲酯之前或之后的一年中均未转诊至专科医生。
