Zito J M, Safer D J, dosReis S, Magder L S, Riddle M A
Department of Pharmacy Practice and Science, University of Maryland at Baltimore 21201, USA.
Psychopharmacol Bull. 1997;33(1):143-7.
Treatment of attentional disorders in America has increased dramatically in recent years. This trend is accounted for partly by lengthening the duration of treatment into adulthood for some individuals as well as by increased treatment among girls. Beyond these factors, the role of economic status, race, and geographic region to explain the variation in methylphenidate use is not well understood. Computerized administrative data were used to explore the influence of several sociodemographic factors on the prevalence of methylphenidate use. The data source consisted of Maryland Medicaid prescription drug reimbursement claims data for FY1991 for children ages 5 to 14 years. In effect, the study was restricted to a sample of patients with limited income. The study aims included (1) measuring gender-, age-, race-, and region-specific methylphenidate prevalence for this restricted income population; (2) comparing the Caucasian:African-American (C:A-A) ratio for methylphenidate with the C:A-A ratio for several drug therapies having non-psychotropic uses, specifically the anti-asthma drug, theophylline, and antibiotics for infections; and (3) estimating the average daily dose of methylphenidate from prescription claims data. Total drug-specific prevalence among the 5-14 year olds was 2.2 percent for methylphenidate while age-specific prevalence varied from 0.4 percent (5 year olds) to 3.4 percent (9 year olds). The gender ratio was 3.7:1 (M:F), confirming the increasing trend for girls to receive this medication. Substantial variation across eight defined regions of the state was observed. Racial differences were pronounced: African-Americans were 2.5 times less likely to receive methylphenidate than Caucasian youths. As hypothesized, non-psychotropic drug use was distinctly different from psychotropic drug use in terms of race: theophylline was 1.5 times more likely to be found for African-Americans than Caucasians, whereas antibiotic prescriptions were 1.5 times more likely to be prescribed to Caucasian youths. Average daily dose of methylphenidate was estimated to be 18.7 +/- 10.4 mg for 5-9 year olds and 26.8 +/- 14.0 mg for 10-14 year olds. This brief report confirms the typically lower rate among African-American Medicaid youths for most prescription drugs. The dramatic racial disparity for the psychotropic agent methylphenidate is a new and compelling finding which should be verified among other economic groups. Diagnostic, referral, and cultural bias should be ruled out as possible explanations for the observed differences.
近年来,美国注意力障碍的治疗显著增加。这一趋势部分归因于一些个体的治疗时间延长至成年期,以及女孩接受治疗的人数增加。除了这些因素外,经济状况、种族和地理区域在解释哌醋甲酯使用差异方面的作用尚未得到充分理解。本研究使用计算机化管理数据来探讨一些社会人口学因素对哌醋甲酯使用流行率的影响。数据来源为1991财年马里兰州医疗补助处方药报销申请数据,涉及5至14岁儿童。实际上,该研究仅限于收入有限的患者样本。研究目的包括:(1)测量该收入受限人群中按性别、年龄、种族和地区划分的哌醋甲酯流行率;(2)比较哌醋甲酯的白种人:非裔美国人(C:A-A)比例与几种非精神药物治疗的C:A-A比例,具体为抗哮喘药物茶碱和抗感染抗生素;(3)根据处方申请数据估算哌醋甲酯的平均日剂量。5至14岁儿童中,哌醋甲酯的总药物特定流行率为2.2%,年龄特定流行率从0.4%(5岁儿童)到3.4%(9岁儿童)不等。性别比为3.7:1(男:女),证实了女孩接受这种药物治疗的趋势在增加。该州八个定义区域存在显著差异。种族差异明显:非裔美国青少年接受哌醋甲酯治疗的可能性比白种人青少年低2.5倍。正如所假设的,非精神药物的使用在种族方面与精神药物的使用明显不同:非裔美国人使用茶碱的可能性比白种人高1.5倍,而抗生素处方开给白种人青少年的可能性比非裔美国人高1.5倍。5至9岁儿童哌醋甲酯的平均日剂量估计为18.7 +/- 10.4毫克,10至14岁儿童为26.8 +/- 14.0毫克。这份简短报告证实了非裔美国医疗补助青少年在大多数处方药使用方面的比率通常较低。精神药物哌醋甲酯存在巨大的种族差异是一个新的、引人注目的发现,应在其他经济群体中得到验证。应排除诊断、转诊和文化偏见作为观察到的差异的可能解释。