Naudon L, Dourmap N, Leroux-Nicollet I, Costentin J
Unité de Neuropsychopharmacologie Expérimentale, U.R.A. 1170 du CNRS, Faculté de Médecine et de Pharmacie de Rouen, Saint Etienne du Rouvray, France.
Brain Res. 1992 Feb 14;572(1-2):247-9. doi: 10.1016/0006-8993(92)90477-q.
Kainic acid lesion of the striatum leads to the disruption of the striatonigral regulatory loop. Although microdialysis showed an increase in dopamine release, two days after kainic acid injection, 3-methoxytyramine levels are dramatically decreased. This suggests that the postsynaptic membrane-bound catechol-O-methyltransferase (COMT), but not the glial COMT, is responsible for the formation of measured 3-methoxytyramine.
纹状体的 kainic 酸损伤导致纹状体黑质调节环路的破坏。尽管微透析显示多巴胺释放增加，但在注射 kainic 酸两天后，3-甲氧基酪胺水平显著降低。这表明，测得的 3-甲氧基酪胺的形成是由突触后膜结合儿茶酚-O-甲基转移酶（COMT）而非胶质 COMT 负责。
