Glover M T, Atherton D J
Hospital for Sick Children, London, U.K.
Clin Exp Allergy. 1992 Apr;22(4):440-6. doi: 10.1111/j.1365-2222.1992.tb00145.x.
A double-blind controlled trial of hyposensitization with tyrosine-adsorbed Dermatophagoides pteronyssinus vaccine in 24 children with atopic eczema and immediate hypersensitivity to D. pteronyssinus failed to demonstrate superiority over placebo after a standard 8 month course of treatment. In a second phase, children initially administered active treatment were randomly allocated to continue with active treatment or switched to placebo for a further 6 months. The clinical scores suggest that prolonged hyposensitization may be more effective than placebo but the numbers were too small to permit confident conclusions. A dramatic placebo effect may have served to conceal any additional therapeutic effect from active treatment.
一项针对24名患有特应性皮炎且对屋尘螨立即过敏的儿童进行的酪氨酸吸附屋尘螨疫苗脱敏的双盲对照试验，在标准的8个月疗程治疗后，未能证明其优于安慰剂。在第二阶段，最初接受积极治疗的儿童被随机分配继续接受积极治疗或改用安慰剂再治疗6个月。临床评分表明，延长脱敏治疗可能比安慰剂更有效，但样本量太小，无法得出确切结论。显著的安慰剂效应可能掩盖了积极治疗的任何额外治疗效果。
