血管紧张素转换酶基因多态性与冠状动脉钙化之间的关联。鹿特丹冠状动脉钙化研究。

The association between angiotensin-converting enzyme gene polymorphism and coronary calcification. The Rotterdam Coronary Calcification Study.

作者信息

Oei Hok-Hay S, Sayed-Tabatabaei Fakhredin A, Hofman Albert, Oudkerk Matthijs, van Duijn Cornelia M, Witteman Jacqueline C M

机构信息

Department of Epidemiology and Biostatistics, Erasmus MC, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

出版信息

Atherosclerosis. 2005 Sep;182(1):169-73. doi: 10.1016/j.atherosclerosis.2005.01.040.

DOI:10.1016/j.atherosclerosis.2005.01.040

PMID:16115488

Abstract

BACKGROUND

An insertion/deletion (I/D) polymorphism in the gene encoding angiotensin-converting enzyme (ACE) has been associated with serum ACE levels. The association between the ACE I/D polymorphism and coronary heart disease is unclear. Electron-beam-computed tomography (EBT) is a technique to non-invasively quantify the amount of coronary calcification. We investigated the association between the ACE I/D polymorphism and coronary calcification.

METHODS AND RESULTS

The Rotterdam Coronary Calcification Study is a population-based study in subjects aged 55 years and over. EBT scanning was performed in 2013 participants. Coronary calcification was quantified according to the Agatston score. The ACE I/D polymorphism was available for 1976 subjects. Geometric mean calcium scores in men with the II, ID and DD genotype were 167, 207 and 219, respectively. However, the difference in calcium score (p=0.19 for ID versus II; p=0.15 for DD versus II) and the trend (ptrend=0.17) were not significant. Calcium scores in women with the II, ID and DD genotype were 44, 42 and 36, respectively. There were no significant differences in calcium score (p=0.78 for ID versus II; p=0.29 for DD versus II), neither was the trend (ptrend=0.27). After we stratified on cardiovascular risk factors, no associations were present.

CONCLUSION

The present study failed to show an association between the ACE I/D polymorphism and coronary calcification in the general population. Also, no significant associations were present between the ACE I/D polymorphism and coronary calcification in strata of cardiovascular risk factors.

摘要

背景

血管紧张素转换酶（ACE）编码基因中的插入/缺失（I/D）多态性与血清ACE水平相关。ACE I/D多态性与冠心病之间的关联尚不清楚。电子束计算机断层扫描（EBT）是一种非侵入性定量冠状动脉钙化量的技术。我们研究了ACE I/D多态性与冠状动脉钙化之间的关联。

方法与结果

鹿特丹冠状动脉钙化研究是一项针对55岁及以上人群的基于人群的研究。对2013名参与者进行了EBT扫描。根据阿加斯顿评分对冠状动脉钙化进行定量。1976名受试者的ACE I/D多态性数据可用。II、ID和DD基因型男性的几何平均钙评分分别为167、207和219。然而，钙评分的差异（ID与II相比，p = 0.19；DD与II相比，p = 0.15）和趋势（p趋势 = 0.17）并不显著。II、ID和DD基因型女性的钙评分分别为44、42和36。钙评分无显著差异（ID与II相比，p = 0.78；DD与II相比，p = 0.29），趋势也不显著（p趋势 = 0.27）。在我们根据心血管危险因素进行分层后，未发现关联。