Fellgiebel A, Müller M J, Mazanek M, Baron K, Beck M, Stoeter P
Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Str. 8, 55131 Mainz, Germany.
Neurology. 2005 Aug 23;65(4):600-2. doi: 10.1212/01.wnl.0000173030.70057.eb.
In male patients with Fabry disease (FD), significant age-related cerebral white matter lesions (WMLs) can be found. Although characteristic symptoms including cerebrovascular events are highly prevalent also in females with FD, cerebral structural changes have not been investigated in female FD patients yet. The authors quantified the WML load of 13 male and 14 age-matched female patients with FD and could demonstrate a comparably high frequency and severity of WMLs in both groups.
在患有法布里病（FD）的男性患者中，可以发现与年龄相关的显著脑白质病变（WMLs）。尽管包括脑血管事件在内的特征性症状在患有FD的女性中也非常普遍，但尚未对女性FD患者的脑结构变化进行研究。作者对13名男性和14名年龄匹配的女性FD患者的WML负荷进行了量化，结果表明两组患者中WMLs的发生频率和严重程度相当高。
