Nadasdi M
Wyeth Limited, North York, Ontario, Canada.
Clin Ther. 1992 Mar-Apr;14(2):236-41.
For a minimum of one month (mean, 54 days), 287 infants and children less than 8 years of age were fed an isolated soy-protein formula. Prior to entry into the study, a cow's milk formula was being fed to 71%, a soy formula to 9%, and cow's milk or other formulas to 20%. Intolerance to cow's milk was reported in 35% of the patients, symptoms indicative of cow's milk intolerance in 23%, diarrhea or gastroenteritis in 18%, a family history of allergy in 13%, and insufficient weight gain, intolerance to other formulas, or constipation in 11%. The patients showed normal increases in weight and length during the study. A significant decrease in the following symptoms were reported in the patients from before to after treatment: abdominal cramps, bloating or gas, colic, diarrhea, fussiness, rashes or eczema, spitting up, waking up crying at night, wheezing, and vomiting. It is concluded that, while receiving soy formula, infants and children continued to thrive normally and that the formula was well tolerated. After receiving soy formula, the frequency of undesirable feeding-related symptoms was reduced in the majority of infants and children.
在至少一个月的时间里（平均54天），对287名8岁以下的婴幼儿喂食了一种分离大豆蛋白配方奶粉。在进入研究之前，71%的患儿正在食用牛奶配方奶粉，9%食用大豆配方奶粉，20%食用牛奶或其他配方奶粉。报告显示，35%的患者对牛奶不耐受，23%有提示牛奶不耐受的症状，18%有腹泻或肠胃炎，13%有过敏家族史，11%有体重增加不足、对其他配方奶粉不耐受或便秘。在研究期间，患者的体重和身高正常增加。报告显示，与治疗前相比，患者以下症状有显著减轻：腹部绞痛、腹胀或胀气、肠绞痛、腹泻、烦躁不安、皮疹或湿疹、吐奶、夜间醒来哭闹、喘息和呕吐。得出的结论是，婴幼儿在食用大豆配方奶粉期间继续正常茁壮成长，并且该配方奶粉耐受性良好。在食用大豆配方奶粉后，大多数婴幼儿与喂食相关的不良症状发生频率降低。
