Overbeek Berno U H, van Alfen Nens, Bor Jose A, Zwarts Machiel J
Department of Clinical Neurophysiology, Radboud University Nijmegen Medical Center, The Netherlands.
Muscle Nerve. 2005 Nov;32(5):613-8. doi: 10.1002/mus.20421.
The sural/radial nerve amplitude ratio (SRAR) has been proposed as a sensitive indicator of early-stage axonal polyneuropathy. However, previous studies did not take into account the effect of sex differences or different calculating methods. To obtain reference values and information on the variability of the SRAR in daily practice, we measured amplitudes of sural and superficial radial sensory nerve action potentials in 106 healthy adults, correlated them with epidemiological variables, and calculated the SRAR in several ways. Our results show that the SRAR is a robust measure, independent of age, weight, sex, or method of calculation. The use of bilateral measurements is recommended. The cut-off value (5th percentile) of 0.2 in these healthy subjects is much lower than found previously, especially compared to defining cut-off values by comparing patients with matched controls. Further study is needed to establish the clinical value of this SRAR in the early detection of axonal polyneuropathies.
腓肠/桡神经振幅比（SRAR）已被提议作为早期轴索性多发性神经病的敏感指标。然而，先前的研究并未考虑性别差异或不同计算方法的影响。为了获得日常实践中SRAR的参考值及变异性信息，我们测量了106名健康成年人的腓肠神经和桡浅感觉神经动作电位的振幅，将它们与流行病学变量相关联，并以多种方式计算了SRAR。我们的结果表明，SRAR是一个可靠的指标，与年龄、体重、性别或计算方法无关。建议采用双侧测量。这些健康受试者中0.2的临界值（第5百分位数）远低于先前发现的值，特别是与通过将患者与匹配的对照组进行比较来确定临界值相比。需要进一步研究以确定该SRAR在轴索性多发性神经病早期检测中的临床价值。
