Mansukhani Khushnuma, Dhonde Mayura, Sreenivasan Aarthika, Sharma Alika, Balakrishnan Lajita, Chavan Priyanka
Clinical Neurophysiology, Bombay Hospital, Mumbai, India.
Neuro-Electrophysiologist, Dhonde Hospital, Nanded, India.
Ann Indian Acad Neurol. 2020 May-Jun;23(3):255-260. doi: 10.4103/aian.AIAN_321_20. Epub 2020 Jun 5.
The amplitude ratio of sural radial sensory nerve action potential is used as a sensitive measure for the diagnosis of an early distal axonal peripheral neuropathy. There is no age-stratified reference data available.
To establish age-stratified sural radial amplitude ratio (SRAR) reference data in healthy Indian subjects.
The study was conducted in the electrodiagnostic laboratory of a tertiary city hospital and is an analytical, prospective, and field trial study.
A prospective study was conducted on 146 healthy volunteers between 18 and 86 years, stratified into 6 groups, a = 18-30 years, b = 31-40 years, c = 41-50 years, d = 51-60 years, e = 61-70 years, and f = >70 years.
Radial amplitude ratio was calculated.
Stata 12.1 statistical program was used. Lower limit of SRAR was obtained (mean-2SD of transformed data). ANOVA defined the intergroup variability, and linear regression and Pearson's correlation assessed the statistical significance.
The lower limit of normal SRAR, for each age group is as follows: a: 0.30, b: 0.23, c: 0.20, d: 0.17, e: 0.17, and f: 0.08. SRAR of groups a, b, c was significantly different from groups e and f. Similarly, SRAR was significantly different between groups d and but not between groups d and e or a, b, c, d.
This study provides age-stratified reference data for SRAR. There is evidence to suggest that SRAR varies with age; hence, a single value of SRAR should not be used when diagnosing a peripheral neuropathy based on this criterion.
腓肠神经-桡神经感觉神经动作电位的波幅比被用作诊断早期远端轴索性周围神经病的一项敏感指标。目前尚无按年龄分层的参考数据。
建立健康印度受试者按年龄分层的腓肠神经-桡神经波幅比（SRAR）参考数据。
本研究在一家三级城市医院的电诊断实验室进行，是一项分析性、前瞻性现场试验研究。
对146名年龄在18至86岁之间的健康志愿者进行了一项前瞻性研究，分为6组，a组=18 - 30岁，b组=31 - 40岁，c组=41 - 50岁，d组=51 - 60岁，e组=61 - 70岁，f组=>70岁。
计算桡神经波幅比。
使用Stata 12.1统计程序。获得SRAR的下限（转换数据的均值-2标准差）。方差分析确定组间变异性，线性回归和Pearson相关性评估统计学意义。
各年龄组SRAR的正常下限如下：a组：0.30，b组：0.23，c组：0.20，d组：0.17，e组：0.17，f组：0.08。a、b、c组的SRAR与e、f组有显著差异。同样，d组与[此处原文似乎有误，可能是某个组别的表述缺失]之间SRAR有显著差异，但d组与e组之间或a、b、c、d组之间无显著差异。
本研究提供了SRAR按年龄分层的参考数据。有证据表明SRAR随年龄变化；因此，基于该标准诊断周围神经病时不应使用单一的SRAR值。
