Søndergaard Kirsten M, Hindsberger Charlotte, Toft Unna, Adser Lene, Damsgaard Jens J, Hvas Anne Charlotte
Københavns Universitet, Panum Instituttet, Central Forskningsenhed for Almen Praksis, Afdeling for Almen Medicin og Biostatistisk Afdeling.
Ugeskr Laeger. 2005 Aug 22;167(34):3180-4.
Middle-aged women are often faced with the dilemma of whether to use hormone therapy or not. Until recently, advertisements, as well as, very often, the scientific literature, advocated the use of hormone therapy. The aim of this study was to determine women's use of hormone therapy and its correlation with age, self-rated health status and lifestyle factors.
An anonymous postal questionnaire was sent to 5,300 women over 44 years of age. The public health insurance office in Roskilde County picked 100 women at random for each of the 53 general practitioners who entered the survey in 1998. 72% of the women answered the questionnaire. The data set was statistically analysed using multiple linear logistic regression, taking account of the fact that the data had been obtained through general practitioners.
35% (95% CI 32-38) of the women 50-55 years of age were currently using or had formerly used hormone therapy. As many as 51% (95% CI 46-56) of the women 60-64 years of age were currently using or had formerly used hormone therapy. More than 50% of the women who were using hormone therapy had done so for more than 10 years. The group of women 45-59 years of age with the worst self-rated health status had odds of 5.1 (95% CI 3.0-8.6) of current or former use of hormone therapy as compared with the women with the highest self-rated health status. The odds of current use of hormone therapy were comparable at 2.7 (95% CI 1.5-4.7) for the women with the lowest self-rated health status as compared with the women with the highest self-rated health status. There was a positive correlation between the use of hormone therapy and physical exercise, tobacco use, former use of oral contraceptives and examination of cholesterol level.
The percentage of women over 44 years of age who currently use or have formerly used hormone therapy in our study is comparable with the results of Danish surveys since 1983. Women 45-59 years of age who use hormone therapy do not have the same high level of self-rated health as that of women aged 45-59 years who have not used hormone therapy.
中年女性常常面临是否使用激素疗法的两难困境。直到最近,广告以及很多时候科学文献都提倡使用激素疗法。本研究的目的是确定女性对激素疗法的使用情况及其与年龄、自我评定的健康状况和生活方式因素的相关性。
向5300名44岁以上的女性发送了一份匿名邮政调查问卷。罗斯基勒县的公共医疗保险办公室为1998年参与调查的53名全科医生中的每一位随机挑选了100名女性。72%的女性回答了问卷。考虑到数据是通过全科医生获取的这一事实,使用多元线性逻辑回归对数据集进行了统计分析。
50 - 55岁的女性中,35%(95%置信区间32 - 38)目前正在使用或曾经使用过激素疗法。60 - 64岁的女性中,多达51%(95%置信区间46 - 56)目前正在使用或曾经使用过激素疗法。超过50%使用激素疗法的女性使用时间已超过10年。自我评定健康状况最差的45 - 59岁女性群体,与自我评定健康状况最佳的女性相比,目前或曾经使用激素疗法的几率为5.1(95%置信区间3.0 - 8.6)。自我评定健康状况最差的女性与自我评定健康状况最佳的女性相比,目前使用激素疗法的几率相当,为2.7(95%置信区间1.5 - 4.7)。激素疗法的使用与体育锻炼、吸烟、既往口服避孕药使用情况和胆固醇水平检查之间存在正相关。
在我们的研究中,44岁以上目前正在使用或曾经使用过激素疗法的女性百分比与自1983年以来丹麦的调查结果相当。45 - 59岁使用激素疗法的女性自我评定的健康水平与未使用激素疗法的45 - 59岁女性不一样高。