Khan Naghma, Sultana Sarwat
Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard University, New Delhi 110 062, India.
J Enzyme Inhib Med Chem. 2005 Jun;20(3):275-83. doi: 10.1080/14756360400028119.
KBrO3-mediated renal injury and hyperproliferative response in Wistar rats. In this communication, we report the efficacy of Nymphaea alba on KBrO3 (125 mg/kg body weight, intraperitoneally) caused reduction in renal glutathione content, renal antioxidant enzymes and phase-II metabolising enzymes with enhancement in xanthine oxidase, lipid peroxidation, gamma-glutamyl transpeptidase and hydrogen peroxide (H202). It also induced blood urea nitrogen, serum creatinine and tumor promotion markers, viz., ornithine decarboxylase (ODC) activity and DNA synthesis. Treatment of rats with Nymphaea alba (100 and 200 mg/kg body weight) one hour before KBrO3 (125 mg/kg body weight, i.p.) resulted in significant decreases in xanthine oxidase (P < 0.05), lipid peroxidation, gamma-glutamyl transpeptidase, H202 generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Renal glutathione content, glutathione metabolizing enzymes and antioxidant enzymes were also recovered to significant levels (P < 0.001). These results show that Nymphaea alba acts as chemopreventive agent against KBrO3-mediated renal injury and hyperproliferative response.
溴酸钾介导的Wistar大鼠肾损伤及细胞过度增殖反应。在本论文中，我们报告了白花睡莲对溴酸钾（125毫克/千克体重，腹腔注射）所致肾谷胱甘肽含量降低、肾抗氧化酶及Ⅱ相代谢酶减少，同时伴有黄嘌呤氧化酶、脂质过氧化、γ-谷氨酰转肽酶及过氧化氢（H2O2）增加的作用效果。它还诱导了血尿素氮、血清肌酐及肿瘤促进标志物，即鸟氨酸脱羧酶（ODC）活性及DNA合成增加。在溴酸钾（125毫克/千克体重，腹腔注射）给药前1小时用白花睡莲（100和200毫克/千克体重）处理大鼠，可使黄嘌呤氧化酶（P < 0.05）、脂质过氧化、γ-谷氨酰转肽酶、H2O2生成、血尿素氮、血清肌酐、肾ODC活性及DNA合成显著降低（P < 0.001）。肾谷胱甘肽含量、谷胱甘肽代谢酶及抗氧化酶也恢复到显著水平（P < 0.001）。这些结果表明，白花睡莲可作为一种化学预防剂，对抗溴酸钾介导的肾损伤及细胞过度增殖反应。
