Zöller J, Zöller B, Hassfeld S, Köhler J
Klinik und Poliklinik für Mund-Kiefer-Gesichtschirurgie Heidelberg.
Dtsch Zahnarztl Z. 1992 Jan;47(1):63-5.
A randomised, prospective study was conducted to compare the efficiency and safety of methods for intravenous conscious sedation in patients undergoing oral surgery under local analgesia. 150 systemically healthy patients (ASA Class I and II) participated. Three groups were formed: group 1 received 0.05 mg/kg midazolam; group 2 0.05 mg/kg midazolam, 1.5 mg/kg tramadol, 50 mg alizaprid; group 3 0.05 mg/kg midazolam, 0.2 mg/kg nalbuphine, 50 mg alizaprid. Blood pressure, heart rate and oxygen saturation were measured throughout the procedure. The results confirmed that the use of nalbuphine (group 3) allows a reduction in the mean dosage of midazolam required to produce satisfactory sedation and effected a more rapid recovery time compared to group 12 and 2. With the combination nalbuphine and alizaprid nausea and vomiting could be reduced for the most part compared to group 2.
进行了一项随机前瞻性研究，以比较局部镇痛下接受口腔手术患者的静脉清醒镇静方法的有效性和安全性。150名全身健康的患者（ASA I级和II级）参与其中。分为三组：第1组接受0.05mg/kg咪达唑仑；第2组接受0.05mg/kg咪达唑仑、1.5mg/kg曲马多、50mg阿立必利；第3组接受0.05mg/kg咪达唑仑、0.2mg/kg纳布啡、50mg阿立必利。在整个手术过程中测量血压、心率和血氧饱和度。结果证实，与第1组和第2组相比，使用纳布啡（第3组）可降低产生满意镇静所需的咪达唑仑平均剂量，并缩短恢复时间。与第2组相比，纳布啡和阿立必利联合使用可在很大程度上减少恶心和呕吐。
