Saumet Jean Louis
UMR CNRS 6188, Circulations Régionales et Micro Circulation, Faculté de médecine, 49045 Angers.
Bull Acad Natl Med. 2005 Jan;189(1):99-105; discussion 105-6.
Prolonged external pressure can cause pressure sores. We examined the link between mechanical sensitivity and cutaneous vasodilation, and its possible alteration in patients at high risk of pressure sores. Clinical and experimental studies have shown that this link, which is not dependent on inflammation or pain, involves capsaicin-sensitive nerve fibers. Receptors for calcitonin gene-related peptide, vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide are also involved, contrary to neurokinin receptors. Endothelial nitric oxide is crucialfor pressure-induced vasodilation. This link is altered in diabetes, even prior to the onset of nervous complications. Restoration of pressure-induced vasodilation might prevent the onset of pressure sores and plantar ulcers in diabetic patients.
长时间的外部压力会导致压疮。我们研究了机械敏感性与皮肤血管舒张之间的联系，以及其在压疮高危患者中可能发生的改变。临床和实验研究表明，这种联系不依赖于炎症或疼痛，涉及对辣椒素敏感的神经纤维。与神经激肽受体相反，降钙素基因相关肽、血管活性肠肽和垂体腺苷酸环化酶激活多肽的受体也参与其中。内皮一氧化氮对压力诱导的血管舒张至关重要。在糖尿病中，即使在神经并发症出现之前，这种联系就已发生改变。恢复压力诱导的血管舒张可能会预防糖尿病患者发生压疮和足底溃疡。
