Matete G O, Kajejo O A
KARI Trypanosomiasis Research Centre, P.O. Box 362, Kikuyu, Kenya.
East Afr Med J. 2005 Jan;82(1):20-3. doi: 10.4314/eamj.v82i1.9289.
To determine possible interaction between infections of Trypanosoma brucei rhodesiense sleeping sickness and HIV/AIDS in Western Kenya.
Random selection and testing for HIV infections of serum samples from HAT patients using an indirect single phase enzyme linked immunosorbent assay (EAI-Immunocomb II, oragenics).
National Sleeping Sickness Referral Hospital-Alupe.
Four (16%) of the HAT serum samples (n = 25) were found to be seropositive for HIV type 1 and 2 infections, while an additional four (16%) were sero-positive to HIV type 2 infections alone. In contrast, the patients from the local STD clinic showed that 52% (n = 53) were seropositive for both HIV type 1 and 2 infections. No patient from the STD clinic was seropositive for HIV type 2 alone. Calculated Yates Chi square value of 17.31 (P > 0.001) indicated a significant increase in HIV type 2 antibodies in T. brucei rhodesiense sleeping sickness patients.
Sixteen percent of the HAT serum samples (n = 25) were found to be seropositive for HIV type 1 and 2 infections, while an additional 16% were sero-positive to HIV type 2 infections alone. In contrast, the patients from the local STD clinic showed that 52% (n = 53) were seropositive for both HIV type 1 and 2 infections. No patient from the STD clinic was seropositive for HIV type 2 alone. Calculated Yates Chi square value of 17.31 (P < 0.001) indicated a significant increase in HIV type 2 antibodies in T. brucei rhodesiense sleeping sickness patients.
T. brucei rhodesiense sleeping sickness is an immuno-suppressive disease whose patients have shown a higher affinity to HIV type 2 infections more common in central and western Africa. Such patients when treated, appear to recover from HAT but later succumb to full-blown AIDS. It is recommended that CD4+ T cell numbers and CD4/CD8 T cell ratios be assessed toinvestigate response to treatment in HIV positive HAT patients.
确定肯尼亚西部罗德西亚布氏锥虫昏睡病感染与艾滋病毒/艾滋病之间可能存在的相互作用。
使用间接单相酶联免疫吸附测定法（EAI-Immunocomb II，oragenics公司）对昏睡病患者的血清样本进行随机选择并检测艾滋病毒感染情况。
国家昏睡病转诊医院——阿鲁佩。
在昏睡病血清样本（n = 25）中，有4份（16%）被检测出1型和2型艾滋病毒感染血清学阳性，另有4份（16%）仅为2型艾滋病毒感染血清学阳性。相比之下，当地性病诊所的患者中，52%（n = 53）的患者1型和2型艾滋病毒感染血清学均为阳性。性病诊所没有患者仅为2型艾滋病毒血清学阳性。计算得出的耶茨卡方值为17.31（P < 0.001），表明罗德西亚布氏锥虫昏睡病患者中2型艾滋病毒抗体显著增加。
在昏睡病血清样本（n = 25）中，有4份（16%）被检测出1型和2型艾滋病毒感染血清学阳性，另有4份（16%）仅为2型艾滋病毒感染血清学阳性。相比之下，当地性病诊所的患者中，52%（n = 53）的患者1型和2型艾滋病毒感染血清学均为阳性。性病诊所没有患者仅为2型艾滋病毒血清学阳性。计算得出的耶茨卡方值为17.31（P < 0.001），表明罗德西亚布氏锥虫昏睡病患者中2型艾滋病毒抗体显著增加。
罗德西亚布氏锥虫昏睡病是一种免疫抑制性疾病，其患者对在非洲中部和西部更为常见的2型艾滋病毒感染表现出更高的易感性。这类患者在接受治疗后，似乎能从昏睡病中康复，但随后会死于全面发作的艾滋病。建议评估艾滋病毒阳性昏睡病患者的CD4 + T细胞数量和CD4/CD8 T细胞比率，以研究其对治疗的反应。
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