Kitamura Y, Yamagishi M, Okazaki K, Umemura T, Imazawa T, Nishikawa A, Matsumoto W, Hirose M
Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Food Chem Toxicol. 2006 Feb;44(2):271-7. doi: 10.1016/j.fct.2004.11.021. Epub 2005 Aug 24.
alpha-Eleostearic acid is one of the conjugated linolenic acids from tung oil, which is obtained from the seeds of Aleurites fordii. The effects of dietary alpha-eleostearic acid (18:3, n-5) on the post-initiation period of 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis were examined using female Sprague-Dawley (SD) rats. For initiation, rats were given subcutaneous injections of 40mg/kg body weight (5 times) and 20mg/kg body weight (3 times) of DMH during the age of 6-8 weeks and a single intragastric administration of 50mg/kg body weight of DMBA at 9 weeks. Then, the animals were treated with 0%, 0.01%, 0.1% or 1.0% alpha-eleostearic acid for 34 weeks. Control rats received the basal diet alone or 1.0% alpha-eleostearic acid without prior initiation treatment. All surviving animals were killed at week 37 of the experiment. There were no statistically significant alterations in any of the parameters for either mammary or colon tumors. These results thus indicate that alpha-eleostearic acid does not exert clear modification effects on DMBA and DMH-induced mammary and colon carcinogenesis, at least under the present experimental conditions.
α-桐酸是桐油中的共轭亚麻酸之一，桐油取自油桐种子。使用雌性斯普拉格-道利（SD）大鼠，研究了膳食α-桐酸（18:3，n-5）对7,12-二甲基苯并[a]蒽（DMBA）和1,2-二甲基肼（DMH）诱导的乳腺癌和结肠癌发生起始后期的影响。对于致癌起始阶段，在6至8周龄时，给大鼠皮下注射40mg/kg体重（共5次）和20mg/kg体重（共3次）的DMH，并在9周龄时给大鼠单次灌胃50mg/kg体重的DMBA。然后，用0%、0.01%、0.1%或1.0%的α-桐酸处理动物34周。对照大鼠单独接受基础饮食或接受1.0%的α-桐酸但无先前的致癌起始处理。在实验的第37周处死所有存活的动物。对于乳腺或结肠肿瘤的任何参数，均未观察到统计学上的显著变化。因此，这些结果表明，至少在目前的实验条件下，α-桐酸对DMBA和DMH诱导的乳腺癌和结肠癌发生没有明显的调节作用。
