乳腺骨髓瘤：3例细针穿刺细胞学检查结果报告
Breast myeloma: a report of 3 cases with fine needle aspiration cytologic findings.
作者信息
Kumar Perikala V, Vasei Mohammad, Daneshbod Yahya, Zakerinia Maryam, Ramzi Mani, Noorani Habib, Bagheri Hadi, Talei Abdul Rasool, Soleimanpour Hossein
机构信息
Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
出版信息
Acta Cytol. 2005 Jul-Aug;49(4):445-8. doi: 10.1159/000326182.
BACKGROUND
Multiple myeloma of the breast is very rare, and the fine needle aspiration (FNA) findings have not been reported before.
CASES
Two cases of multiple myeloma presented with bilateral breast nodules during treatment with chemotherapy. One case of multiple myeloma presented initially with a left breast mass. FNA smears of all 3 cases revealed numerous plasma cells, plasmablasts and multinucleated giant plasma cells. The smears were diagnosed as plasma cell tumors. Serum immunoelectrophoresis revealed IgG myeloma in 2 cases and IgA myeloma in 1. Marrow aspirates revealed > 30% plasma cells. Two patients died, and 1 was alive at this writing.
CONCLUSION
The aspiration cytology findings of myeloma can be confuse, with primary and secondary tumors of the breast. The previous clinical history and ancillary studies, such as bone marrow study and serum immunoelectrophoresis, are essential to the correct diagnosis.
背景
乳腺多发性骨髓瘤非常罕见，之前尚未有细针穿刺抽吸（FNA）结果的报道。
病例
2例多发性骨髓瘤患者在化疗期间出现双侧乳腺结节。1例多发性骨髓瘤患者最初表现为左乳肿块。所有3例患者的FNA涂片均显示大量浆细胞、成浆细胞和多核巨浆细胞。涂片诊断为浆细胞瘤。血清免疫电泳显示2例为IgG骨髓瘤，1例为IgA骨髓瘤。骨髓穿刺显示浆细胞>30%。2例患者死亡，撰写本文时1例存活。
结论
骨髓瘤的穿刺细胞学结果可能与乳腺原发性和继发性肿瘤相混淆。既往临床病史和辅助检查，如骨髓检查和血清免疫电泳，对于正确诊断至关重要。
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