Goel Garima, Rai Sharada, Naik Ramadas, Gupta Astha, Baliga Poornima, Sinha Ruchi
Department of Pathology, Kasturba Medical College, Manipal, Karnataka, India.
Acta Cytol. 2010 May-Jun;54(3):255-8. doi: 10.1159/000325031.
Extramedullary plasmacytoma (EMP) constitutes approximately 4% of all plasma cell neoplasms. It may present as the sole manifestation of plasma cell neoplasm, as a solitary plasmacytoma of the bone or as a consequence of multiple myeloma. This study was done to determine the role of fine needle aspiration cytology (FNAC) in the diagnosis of EMP.
In our study 8 cases of EMP at various sites were diagnosed on FNAC. In 3 patients EMP was the initial presentation of plasma cell neoplasm. In the remaining 5 patients the tumors occurred during the course of treatment for multiple myeloma.
The lesions were located at various anatomic sites, including lymph node, scalp, breast, jaw, rib, clavicle and soft tissue swelling in the retrosternal region. The smears prepared from the aspirates in all cases revealed numerous plasma cells at various stages of maturation, leading to a diagnosis of EMP. Radiologic and bone marrow findings also substantiated the diagnosis of multiple myeloma in all but 1 case.
FNAC offers a rapid, reliable and accurate diagnosis of EMP and thus allows initiation of appropriate treatment.
髓外浆细胞瘤（EMP）约占所有浆细胞肿瘤的4%。它可能作为浆细胞肿瘤的唯一表现形式出现，表现为骨的孤立性浆细胞瘤或作为多发性骨髓瘤的结果。本研究旨在确定细针穿刺细胞学检查（FNAC）在EMP诊断中的作用。
在我们的研究中，通过FNAC诊断了8例不同部位的EMP。3例患者中，EMP是浆细胞肿瘤的初始表现。其余5例患者的肿瘤发生在多发性骨髓瘤的治疗过程中。
病变位于不同的解剖部位，包括淋巴结、头皮、乳腺、颌骨、肋骨、锁骨以及胸骨后区域的软组织肿胀。所有病例穿刺抽吸物制备的涂片均显示出处于不同成熟阶段的大量浆细胞，从而诊断为EMP。除1例病例外，放射学和骨髓检查结果也证实了多发性骨髓瘤的诊断。
FNAC能够快速、可靠且准确地诊断EMP，从而能够启动适当的治疗。
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