Machura Edyta, Halkiewicz Franciszek, Mazur Bogdan, Kwiecień Jarosław, Karczewska Krystyna
Klinika Gastroenterologii Alergologii i Zaburzeń Rozwoju Wieku Dzieciecego w Zabrzu.
Pol Merkur Lekarski. 2005 Jun;18(108):620-3.
Clinical symptoms, IgE, and eosinophil counts are insufficient for establishing diagnosis of asthma in young children. It has been suggested that other serum markers might be useful for supporting diagnosis. The aim of the study was to determine serum levels of IL-4, IL-10, and IL-12 in young children with recurrent wheezy bronchitis. We investigated if there was a relationship between those markers and the maintenance clinical symptoms during a 2-year follow-up period. The study involved 30 young children (average age--22.5 months) with recurrent wheezy bronchitis. Control group consisted of 15 healthy children at the same average age. The serum levels of IL-10 (p<0.0006) and IL-12 (p<0.000005) were significantly increased and the serum level of IL-4 was significantly decreased (p<0.00009) in children with wheezing compared with healthy control. However the serum level of IL-10 (p<0.004, R=0.5) and IL-12 (p<0.001, R=0.54) was positively correlated with a number of episodes wheezing in the past. Children with wheezing and skin rash showed a significantly higher level of IL-4 (p<0.02) and lower levels of IL-10 (p<0.0008) and IL-12 (p<0.005) compared with children without skin rash. No statistically significant differences in serum levels of IL-4, IL-10, and IL-12 were observed between children with persistent wheezing during a 2-year follow-up period and children without respiratory symptoms. This study suggested a potential role cytokines in recurrent wheezing, but follow-up of the children is needed to evaluate the prognostic value of serum cytokines for development asthma in later childhood.
临床症状、免疫球蛋白E（IgE）及嗜酸性粒细胞计数不足以确诊幼儿哮喘。有观点认为其他血清标志物可能有助于辅助诊断。本研究旨在测定复发性喘息性支气管炎幼儿的白细胞介素-4（IL-4）、白细胞介素-10（IL-10）和白细胞介素-12（IL-12）血清水平。我们调查了这些标志物与2年随访期内持续临床症状之间是否存在关联。该研究纳入了30名患有复发性喘息性支气管炎的幼儿（平均年龄22.5个月）。对照组由15名平均年龄相同的健康儿童组成。与健康对照组相比，喘息儿童的IL-10血清水平显著升高（p<0.0006）、IL-12血清水平显著升高（p<0.000005），而IL-4血清水平显著降低（p<0.00009）。然而，IL-10血清水平（p<0.004，R=0.5）和IL-12血清水平（p<0.001，R=0.54）与既往喘息发作次数呈正相关。与无皮疹的儿童相比，伴有喘息和皮疹的儿童IL-4水平显著更高（p<0.02），IL-10水平更低（p<0.0008），IL-12水平更低（p<0.005）。在2年随访期内持续喘息的儿童与无呼吸道症状的儿童之间，未观察到IL-4、IL-10和IL-12血清水平有统计学显著差异。本研究提示细胞因子在复发性喘息中可能发挥作用，但需要对这些儿童进行随访，以评估血清细胞因子对儿童后期哮喘发展的预后价值。
