Gasiorowska Joanna, Czerwionka-Szaflarska Mieczysława, Swincow Grazyna, Gruszka Marzena, Odrowaz-Sypniewska Grazyna
Nicolaus Copernicus University in Toruń, Collegium Medicum of Bydgoszcz, Poland.
Pol Merkur Lekarski. 2006 Dec;21(126):516-21.
Wheezy bronchitis is one of hospitalization causes of infants and young children. Significant problem is recurrent wheezing. Wheezy bronchitis can be the first sign of bronchial asthma. New markers are taken into consideration in aspect of recurrent bronchitis prevention. Such marker seems to be tryptase. Tryptase is released from mastocytes in early phase of allergic reaction. The aim of the study was to assess tryptase and ECP concentrations among infants and young children with wheezy bronchitis.
Ninety-four patients with wheezy bronchitis in age from between 1 month to 36 months old were included into the study (47 with the first episode and 47 with at least third episode). Forty-three patients hospitalized due to other causes, from the same age group (these patients haven't already had any wheezy bronchitis) were included into the control group. Among all patients concentrations of tryptase and ECP were evaluated (among patients from the study group in the acute phase of disease) by fluoroimmunoenzymatic method (FEIA) with the the use of UniCAP 100 set (Pharmacia & Upjohn Diagnostics AB).
No statistically significant differences of tryptase concentrations in blood plasma during wheezy bronchitis among infants and young children in correlation to the control group were found. Statistically significant differences were identified in aspect of tryptase concentrations during wheezy bronchitis between patients with the first episode of wheezing and patients with recurrent wheezing and higher concentrations were observed among patients with the first episode. No statistically significant influence of family history of allergy and symptoms of allergy were identified in aspect of tryptase concentrations.
Obtained results lead to conclusion that tryptase concentrations have a little significance in wheezy bronchitis.
喘息性支气管炎是婴幼儿住院的原因之一。一个重要问题是反复喘息。喘息性支气管炎可能是支气管哮喘的首发症状。在预防反复支气管炎方面正在考虑新的标志物。这样的标志物似乎是类胰蛋白酶。类胰蛋白酶在过敏反应早期从肥大细胞中释放出来。本研究的目的是评估喘息性支气管炎婴幼儿的类胰蛋白酶和嗜酸性粒细胞阳离子蛋白（ECP）浓度。
94例年龄在1个月至36个月的喘息性支气管炎患者纳入研究（47例为首次发作，47例为至少第三次发作）。43例因其他原因住院的同年龄组患者（这些患者尚未患过任何喘息性支气管炎）纳入对照组。通过使用UniCAP 100检测系统（Pharmacia & Upjohn Diagnostics AB）的荧光免疫酶法（FEIA）评估所有患者的类胰蛋白酶和ECP浓度（研究组患者在疾病急性期）。
未发现喘息性支气管炎婴幼儿血浆中类胰蛋白酶浓度与对照组相比有统计学显著差异。在喘息性支气管炎期间，首次喘息发作患者与反复喘息患者的类胰蛋白酶浓度方面存在统计学显著差异，且首次发作患者中观察到浓度更高。在类胰蛋白酶浓度方面，未发现过敏家族史和过敏症状有统计学显著影响。
所得结果得出结论，类胰蛋白酶浓度在喘息性支气管炎中意义不大。
