Michaud Martin, Dumont Marie, Paquet Jean, Desautels Alex, Fantini Maria Livia, Montplaisir Jacques
Sleep Disorders Center, Sacré-Coeur Hospital Montreal, Quebec, Canada.
Sleep. 2005 Jul;28(7):843-6. doi: 10.1093/sleep/28.7.843.
It is now well established that symptoms of restless legs syndrome (RLS) are worsened by immobility and that their severity fluctuates according to a circadian pattern with a maximum occurring in the late evening or during the night. However, no study has ever attempted to dissociate these two effects. The objective of this study was to evaluate the nycthemeral variations in the effects of duration of immobility on symptoms of RLS.
A 28-hour modified constant routine protocol.
Sleep Disorders Center, Montreal Sacré-Coeur Hospital.
Seven patients with primary RLS (3 men, 4 women; mean age: 43.9 years) and seven controls matched for age (42.4 years) and gender.
None.
A 40-minute Suggested Immobilization Test (SIT) was repeated every 2 hours during the 28-hour protocol in order to quantify both subjective leg discomfort and periodic leg movements (PLM). Regarding leg discomfort, a two-way ANOVA performed on patients' data revealed a significant interaction (p = 0.037) between Time within the SIT and Time of day. Simple effect analyses performed to decompose the interaction showed that the increase in leg discomfort with duration of immobility was found only on SIT 7, 8, 9, 10 and 12, which corresponds to the period between 21:20 and 08:00. In addition, in patients, a significant circadian variation (p < 0.01) was found for the 28-hour profiles of leg discomfort progression during the SIT. No interaction or Time within the SIT effect was found for controls.
These results show that worsening of RLS symptoms by immobility is closely linked to their intrinsic circadian variation.
目前已充分证实，不活动会加重不宁腿综合征（RLS）的症状，且其严重程度会根据昼夜节律模式波动，在傍晚或夜间达到最大值。然而，尚无研究试图区分这两种影响。本研究的目的是评估不活动持续时间对RLS症状影响的昼夜变化。
一项28小时的改良固定作息方案。
蒙特利尔圣心医院睡眠障碍中心。
7例原发性RLS患者（3例男性，4例女性；平均年龄：43.9岁）和7例年龄（42.4岁）及性别匹配的对照者。
无。
在28小时的方案中，每2小时重复一次40分钟的建议固定测试（SIT），以量化主观腿部不适和周期性腿部运动（PLM）。关于腿部不适，对患者数据进行的双向方差分析显示，SIT内时间和一天中的时间之间存在显著交互作用（p = 0.037）。为分解该交互作用而进行的简单效应分析表明，仅在SIT 7、8、9、10和12上发现腿部不适随不活动持续时间的增加，这对应于21:20至08:00之间的时间段。此外，在患者中，发现SIT期间腿部不适进展的28小时曲线存在显著的昼夜变化（p < 0.01）。对照者未发现交互作用或SIT内时间效应。
这些结果表明，不活动导致的RLS症状恶化与它们固有的昼夜变化密切相关。
