Bai Haiyun, Li Shuo, Yin Feng, Hu Lihong
National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, CAS, Shanghai, 201203, People's Republic of China.
J Nat Prod. 2005 Aug;68(8):1159-63. doi: 10.1021/np050019l.
Three new compounds designated as firmianones A, B, and C (1-3), along with 13 known compounds, were isolated from the roots of Firmiana platanifolia. Their structures were elucidated by interpretation of HRESIMS, 1H-1H COSY, HMQC, HMBC, and NOESY. The absolute configurations of firmianones A and B with a rare hexacyclic skeleton were determined by CD exciton-coupling experiments. Firmianones A and B exhibited moderate cytotoxicity to the P388 cancer cell line.
从梧桐的根部分离出三种新化合物，分别命名为梧桐酮A、B和C（1-3），以及13种已知化合物。通过对高分辨电喷雾电离质谱（HRESIMS）、氢-氢化学位移相关谱（1H-1H COSY）、异核多量子相干谱（HMQC）、异核多键相关谱（HMBC）和核Overhauser效应谱（NOESY）的解析确定了它们的结构。通过圆二色激子耦合实验确定了具有罕见六环骨架的梧桐酮A和B的绝对构型。梧桐酮A和B对P388癌细胞系表现出中等细胞毒性。
