抗肿瘤剂。233. 兰塔卢克拉汀A - F，来自马缨丹的新型细胞毒性萘醌类化合物。

Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata.

作者信息

Hayashi Ken-ichiro, Chang Fang-Rong, Nakanishi Yuka, Bastow Kenneth F, Cragg Gordon, McPhail Andrew T, Nozaki Hiroshi, Lee Kuo-Hsiung

机构信息

Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

出版信息

J Nat Prod. 2004 Jun;67(6):990-3. doi: 10.1021/np030450f.

DOI:10.1021/np030450f

PMID:15217280

Abstract

In a continuing study to isolate novel antitumor agents from rainforest plants, three new isopropenylfurano-beta-naphthoquinones, designated lantalucratins A (1), B (2), and C (3), and three new isoprenyl-alpha-naphthoquinones, designated lantalucratins D (4), E (5), and F (6), were isolated from Lantana involucrata. Their structures were determined on the basis of NMR and X-ray crystallographic analyses. Compounds 1 and 2 showed cytotoxic activities against various human tumor cell lines, including drug-resistant variants, with IC50 values of 1.0-4.9 microM.

摘要

在一项持续进行的从雨林植物中分离新型抗肿瘤剂的研究中，从马缨丹中分离出了三种新的异丙烯基呋喃-β-萘醌，命名为兰他卢克拉汀A（1）、B（2）和C（3），以及三种新的异戊二烯基-α-萘醌，命名为兰他卢克拉汀D（4）、E（5）和F（6）。它们的结构通过核磁共振和X射线晶体学分析得以确定。化合物1和2对包括耐药变体在内的多种人类肿瘤细胞系显示出细胞毒性活性，IC50值为1.0 - 4.9微摩尔。