刺桐皂苷A - E，来自刺桐的三萜皂苷。

Pursaethosides A-E, triterpene saponins from Entada pursaetha.

作者信息

Tapondjou Azefack Léon, Miyamoto Tomofumi, Mirjolet Jean-François, Guilbaud Nicolas, Lacaille-Dubois Marie-Aleth

机构信息

Laboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, UMIB EA3660, Faculté de Pharmacie, Université de Bourgogne, 7, Bd Jeanne d'Arc, BP 87900, F-21079, Dijon Cedex, France.

出版信息

J Nat Prod. 2005 Aug;68(8):1185-90. doi: 10.1021/np0580311.

DOI:10.1021/np0580311

PMID:16124758

Abstract

Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the n-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.

摘要

从过岗龙种子仁的正丁醇提取物中分离出5个新的三萜皂苷，即过岗龙皂苷A-E（1-5），以及已知的菜豆素。1-5的结构主要通过光谱数据解析和化学降解得以阐明。过岗龙皂苷C-E（3-5）具有一个共同的结构特征，即以对映贝壳杉烯酸作为苷元，这在三萜皂苷中较为罕见。当用HCT 116和HT-29人结肠癌细胞进行测试时，发现化合物2-4和菜豆素没有细胞毒性。