来自非洲榼藤子的抗增殖三萜皂苷

Antiproliferative triterpene saponins from Entada africana.

作者信息

Cioffi Giuseppina, Dal Piaz Fabrizio, De Caprariis Paolo, Sanogo Rokia, Marzocco Stefania, Autore Giuseppina, De Tommasi Nunziatina

机构信息

Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy.

出版信息

J Nat Prod. 2006 Sep;69(9):1323-9. doi: 10.1021/np060257w.

DOI:10.1021/np060257w

PMID:16989528

Abstract

Nine new ester saponins (1-9) were isolated from the roots of Entada africana. Their structures were elucidated by 1D and 2D NMR experiments including 1D and 2D TOCSY, DQF-COSY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis, and chemical methods. The aglycon moieties were found to be echinocystic acid for compounds 1, 2, 4-6, 8, and 9 and acacic acid for 3 and 7. All isolated compounds were tested for their antiproliferative activity against the J774.A1, HEK-293, and WEHI-164 cell lines. Moderate to high cytotoxic potency was found for almost all compounds tested.

摘要

从非洲榼藤的根部分离出了9种新的酯皂苷（1-9）。通过一维和二维核磁共振实验（包括一维和二维全相关谱、双量子滤波相关谱、异核单量子相干谱和异核多键相关谱）以及电喷雾离子化质谱分析和化学方法阐明了它们的结构。发现化合物1、2、4-6、8和9的苷元部分为海胆酸，3和7的苷元部分为阿拉伯胶酸。对所有分离出的化合物针对J774.A1、HEK-293和WEHI-164细胞系进行了抗增殖活性测试。几乎所有测试的化合物都表现出中度至高细胞毒性效力。