Moav B, McKeown B A
Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.
Horm Metab Res. 1992 Jan;24(1):10-4. doi: 10.1055/s-2007-1003242.
Treatment of young rainbow trout (Oncorhynchus mykiss) fish for one week with thyroid hormone (T3) (3,3',5-triiodo-L-thyronine) increased the steady state levels of mRNA for growth hormone in the pituitary 3-4 times as compared to control groups. The steady state levels of growth hormone in the pituitary and in the plasma, were not significantly altered. This implicates the existence in fish of a molecular mechanism of transcriptional stimulation of the GH gene by thyroid hormone, similar to that observed in the rat. These results may explain part of the known anabolic effects of thyroid hormone in fish.
用甲状腺激素（T3，即3,3',5-三碘-L-甲状腺原氨酸）对幼年虹鳟鱼（Oncorhynchus mykiss）进行为期一周的处理后，与对照组相比，垂体中生长激素mRNA的稳态水平提高了3至4倍。垂体和血浆中生长激素的稳态水平没有显著变化。这表明鱼类中存在一种甲状腺激素对生长激素基因转录刺激的分子机制，类似于在大鼠中观察到的情况。这些结果可能解释了甲状腺激素在鱼类中已知的部分合成代谢作用。
