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植入式除颤器患者心律失常风暴的治疗。

Treatment of arrhythmic storm in implantable defibrillator patients.

作者信息

Krivan Lubomír, Kozák Milan, Sepsi Milan, Svobodník Adam, Spinar Jinrich

机构信息

Department of Medicine and Cardiology, University Hospital Bohunice, Brno, Czech Republic.

出版信息

Med Sci Monit. 2005 Sep;11(9):CR426-9. Epub 2005 Aug 26.

Abstract

BACKGROUND

A common ICD therapy-related complication is arrhythmic storm (AS). The objective of our study was to define the impact of AS on patients' prognoses in order to compare the total mortality of AS patients with the rest of the group.

MATERIAL/METHODS: We studied 138 patients who received ICDs between 1994 and 2001. Patients who experienced one or more arrhythmic storms were statistically compared with patients who had no accumulation of malignant arrhythmia or no episodes.

RESULTS

One thousand four hundred ninety episodes of arrhythmia were analyzed. Arrhythmia recurrence was present in 71% of the patients. The majority of episodes (78%) were ventricular tachycardias and only 3% of episodes were ventricular fibrillation. Seventy percent of all arrhythmic episodes were asymptomatic. The ICD therapy sensitivity was 99.7%. Thirty-eight arrhythmic storms in 19 patients (14%) were observed during follow-up. The occurrence of AS was twice as high among patients with LVEF <35% than the rest of the group (18% vs. 8%). The total survival of patients with AS was significantly lower than that of the ICD patients who did not experience an AS (36.8% vs. 16.8%, p=0.042). All episodes of arrhythmic clusters during the AS were ventricular tachycardias.

CONCLUSIONS

Arrhythmic storm is a serious risk marker for cardiac death. Ventricular tachycardia is a basic rhythm disorder of AS episodes and occurs significantly more often than ventricular fibrillation. Arrhythmic storm is responsible for a 4.6 times more frequent re-admission to hospital.

摘要

背景

心律失常风暴(AS)是一种常见的与植入式心律转复除颤器(ICD)治疗相关的并发症。我们研究的目的是确定AS对患者预后的影响,以便比较AS患者与该组其他患者的总死亡率。

材料/方法:我们研究了1994年至2001年间接受ICD治疗的138例患者。对经历过一次或多次心律失常风暴的患者与未发生恶性心律失常累积或未发作的患者进行统计学比较。

结果

分析了1490次心律失常发作。71%的患者出现心律失常复发。大多数发作(78%)为室性心动过速,只有3%的发作是心室颤动。所有心律失常发作中有70%是无症状的。ICD治疗的敏感性为99.7%。随访期间观察到19例患者(14%)发生了38次心律失常风暴。左心室射血分数(LVEF)<35%的患者中AS的发生率是该组其他患者的两倍(18%对8%)。AS患者的总生存率显著低于未经历AS的ICD患者(36.8%对16.8%,p = 0.042)。AS期间所有心律失常簇发作均为室性心动过速。

结论

心律失常风暴是心脏死亡的严重风险标志物。室性心动过速是AS发作的基本节律紊乱,其发生频率明显高于心室颤动。心律失常风暴导致再次入院的频率高出4.6倍。

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